epiregulon

Description

Gene regulatory networks model the underlying gene regulation hierarchies that drive gene expression and observed phenotypes. Epiregulon infers TF activity in single cells by constructing a gene regulatory network (regulons). This is achieved through integration of scATAC-seq and scRNA-seq data and incorporation of public bulk TF ChIP-seq data. Links between regulatory elements and their target genes are established by computing correlations between chromatin accessibility and gene expressions.

Code

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Topics

Depended on by (1)

People

• Xiaosai Yao author maintainer
• Shang-Yang Chen author
• Aaron Lun author
• Tomasz Włodarczyk author