imcRtools

Description

This R package supports the handling and analysis of imaging mass cytometry and other highly multiplexed imaging data. The main functionality includes reading in single-cell data after image segmentation and measurement, data formatting to perform channel spillover correction and a number of spatial analysis approaches. First, cell-cell interactions are detected via spatial graph construction; these graphs can be visualized with cells representing nodes and interactions representing edges. Furthermore, per cell, its direct neighbours are summarized to allow spatial clustering. Per image/grouping level, interactions between types of cells are counted, averaged and compared against random permutations. In that way, types of cells that interact more (attraction) or less (avoidance) frequently than expected by chance are detected.

Code

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Topics

Depended on by (2)

People

• Daniel Schulz contributor maintainer
• Schiller Chiara contributor
• Nils Eling author
• Jana Fischer contributor
• Tobias Hoch contributor
• Lutz Marlene contributor
• Lasse Meyer contributor
• Ibañez Victor contributor
• Vito Zanotelli contributor