nlmixr2est

6.0.1

Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

15packages depend

25.1Kdownloads / year

–test coverage

6/13checks pass

Overview

About

Maintained by Matthew FidlerFirst published 2022-05-1228 releasesCRAN page ↗GitHub ↗

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 doi:10.1007/s10928-015-9409-1). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 doi:10.1002/psp4.12052).

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)

install.packages("nlmixr2est", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("nlmixr2/nlmixr2est")

Development version from nlmixr2/nlmixr2est. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-nlmixr2est

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-nlmixr2est

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

Health

CRAN checks

3ERROR4NOTE6OK

Failing flavors

NOTE r-devel-linux-x86_64-debian-clang
NOTE r-devel-linux-x86_64-debian-gcc
NOTE r-devel-linux-x86_64-fedora-clang
NOTE r-devel-linux-x86_64-fedora-gcc
ERROR r-devel-windows-x86_64
ERROR r-oldrel-windows-x86_64
ERROR r-release-windows-x86_64

Slowest check: 12.6 min · r-oldrel-windows-x86_64

Code health

Yes

Tests · ratio 0.39

not tracked

Coverage

100%

Documentation · exports

Dependencies · direct

Check history

ERROR2026-07-23
7 OK · 4 NOTE · 0 WARNING · 2 ERROR · 0 FAILURE
NOTE2026-07-16
11 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
OK2026-04-25
12 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
NOTE2026-04-22
12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-04-18
11 OK · 2 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE

Show 1 earlier snapshots

NOTE2026-03-10
11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMENoVignettesNopkgdown siteNoNEWSYes · 100% structuredCode of conductNoContributing guideNo

Examples that run: 45%
Documented parameters: 99%
Return-value docs: 97%
References docs: 2%

Downloads

25.1K

CRAN downloads in the past year

Rank #2,917 · ~69/day · ~2.1K/mo

Releases R versions

Daily download trend is not available in this view yet.

1.6K30 days

5.4K90 days

25.1K1 year

Compare downloads with other packages →

Also on898 r2u17K conda_forge38 c2d4u

Repository

GitHub ↗ nlmixr2/nlmixr2est

14Stars

6Forks

45Open issues

4Open PRs

27Releases

6,315Commits

19Contributors

License GPL-2.0 · 6,315 commits · Last activity 2026-07-27

Issues over time

2026-07-14 · 772026-07-28 · 46

Repository practices

Upstream repositoryBeta

6 development-tooling and community-health practices detected across 5 families in the upstream repository

Checks run against github.com/nlmixr2/nlmixr2est on 2026-07-26.

Continuous integration (1)

GitHub Actions

Reproducibility and dev environment (1)

data-raw/

CRAN release process (2)

cran-comments.mdCRAN-SUBMISSION

Docs source (1)

README.Rmd

Show all practices

Coverage (1)

Codecov

How this is detected·Detection ruleset v1 (2026-07-18)

Dependencies

Declared dependencies

41 external dependencies (excludes base and recommended)

Depends (2)

R >= 4.1.0nlmixr2data

Imports (18)

backports checkmate cligraphicsknitr lbfgsb3c lotriMatrixmethodsminqa n1qn1nlmeRcpp rex rxode2statssymengineutils

LinkingTo (8)

BH n1qn1 lbfgsb3c lotri (>= 0.5.0)Rcpp RcppArmadillo RcppEigen rxode2

Suggests (20)

broom.mixed crayon data.table devtools digest dplyr (>= 1.1.0)generics nloptr qs2 sys testthat tibble withr xgxr sfsmisc minpack.lm remotes fastGHQuad rmarkdown rlang

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

15direct

0indirect

admixr2 babelmixr2 nlmixr2 nlmixr2auto nlmixr2autoinit nlmixr2extra nlmixr2lib nlmixr2plot nlmixr2rpt nlmixr2targets shinyMixR xpose.nlmixr2 ggPMX nlmixr2save xpose.xtras

Code & Tests

Datasets

People & History

People (24)

Maintainer (1)

Matthew Fidler

Author, Maintainer

Authors (7)

Author, Maintainer

Author

Author

Author

Author

Author

Author

Contributors (14)

Mahmoud Abdelwahab

Contributor

Hajar Besbassi

Contributor · added in 6.0.0

Contributor

Contributor

Contributor

Contributor

Contributor

Contributor

Show 6 more contributors

Contributor

Contributor

Contributor

Contributor

Contributor

Contributor

Package Timeline

28 releases. Pick two to compare their code metrics. R releases are shown for context.

6.0.1Latest
2026-06-03 · current release · diff ↗
6.0.0
2026-05-31 · diff ↗
R
R 4.6.0 released · 2026-04-24
5.0.2
2025-11-28 · diff ↗
4.1.1
2025-10-09 · diff ↗
4.1.0
2025-08-29 · diff ↗
4.0.2
2025-07-25 · diff ↗
4.0.1
2025-07-20 · diff ↗
4.0.0
2025-07-16 · diff ↗
R
R 4.5.0 released · 2025-04-11
3.0.4
2025-02-19 · diff ↗
3.0.3
2025-01-18 · diff ↗
3.0.2
2024-11-23 · diff ↗
3.0.1
2024-10-23 · diff ↗
3.0.0
2024-09-18 · diff ↗
2.2.2
2024-05-28 · diff ↗

Show 17 earlier events

R
R 4.4.0 released · 2024-04-24
2.2.1
2024-01-31 · diff ↗
2.2.0
2023-12-12 · diff ↗
2.1.8
2023-10-08 · diff ↗
2.1.7
2023-09-19 · diff ↗
2.1.6
2023-05-26 · diff ↗
2.1.5
2023-04-22 · diff ↗
R
R 4.3.0 released · 2023-04-21
2.1.4
2023-04-02 · diff ↗
2.1.3
2022-11-10 · diff ↗
2.1.2
2022-11-02 · diff ↗
2.1.1
2022-10-22 · diff ↗
2.1.0
2022-10-19 · diff ↗
2.0.8
2022-06-22 · diff ↗
2.0.7
2022-05-23 · diff ↗
2.0.6
2022-05-12
R
R 4.2.0 released · 2022-04-22

Package metadata

First published: 2022-05-12
Total releases: 28 / 4 yrs
License: GPL (>= 3) OSI
Minimum R: ≥ 4.1.0
Bundled data: 2.3 KB / 1 file
Download size: 1.1 MB
Installed size: not tracked yet
With dependencies: not tracked yet

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