mmrm

Overview

About

Maintained by Daniel Sabanes BoveFirst published 2022-10-1816 releasesCRAN page ↗GitHub ↗

Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see Cnaan, Laird and Slasor (1997) doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E for a tutorial and Mallinckrodt, Lane, Schnell, Peng and Mancuso (2008) doi:10.1177/009286150804200402 for a review. This package implements MMRM based on the marginal linear model without random effects using Template Model Builder ('TMB') which enables fast and robust model fitting. Users can specify a variety of covariance matrices, weight observations, fit models with restricted or standard maximum likelihood inference, perform hypothesis testing with Satterthwaite or Kenward-Roger adjustment, and extract least square means estimates by using 'emmeans'.

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("mmrm", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("openpharma/mmrm")

Development version from openpharma/mmrm. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-mmrm

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-mmrm

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-mmrm

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

13OK

Slowest check: 18.5 min · r-oldrel-windows-x86_64

Code health

Yes

Tests · ratio 1.99

97.4%

Coverage · measured lines

100%

Documentation · exports

15

Dependencies · direct

Check history

OK2026-07-18
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
WARNING2026-07-16
12 OK · 0 NOTE · 1 WARNING · 0 ERROR · 0 FAILURE
OK2026-06-23
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-06-20
12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
OK2026-06-12
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Show 6 earlier snapshots

ERROR2026-06-05
12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
OK2026-05-07
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-04-23
10 OK · 3 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
NOTE2026-04-22
11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-04-18
10 OK · 3 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
NOTE2026-03-10
11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMENoVignettesYes · dynamicpkgdown siteNoNEWSYes · 100% structuredCode of conductNoContributing guideNo

Examples that run: 100%
Documented parameters: 89%
Return-value docs: 93%
References docs: 1%

Downloads

90.9K

CRAN downloads in the past year

Rank #1,440 · ~249/day · ~7.6K/mo

Releases R versions

Daily download trend is not available in this view yet.

6.1K30 days

21.8K90 days

90.9K1 year

Compare downloads with other packages →

Also on779 r2u37 autocran1.2K conda_forge41 c2d4u

Repository

GitHub ↗ openpharma/mmrm

159Stars

28Forks

22Open issues

0Open PRs

13Releases

430Commits

30Contributors

430 commits · Last activity 2026-07-02 · +0.6% stars, 30d

Stars over time

2025-07-08 · 1422026-07-07 · 159

Repository practices

Upstream repositoryBeta

11 development-tooling and community-health practices detected across 6 families in the upstream repository

Checks run against github.com/openpharma/mmrm on 2026-07-19.

Continuous integration (1)

GitHub Actions

Reproducibility and dev environment (1)

data-raw/

Docs source (1)

README.Rmd

Automation and maintenance (1)

pre-commit

Show all practices

Lint, format, editor (3)

lintrAirRStudio project

Governance and community (4)

Issue templatesPR templateFundingCODEOWNERS

How this is detected·Detection ruleset v1 (2026-07-18)

Dependencies

Declared dependencies

39 external dependencies (excludes base and recommended)

Depends (1)

R >= 4.1

Imports (15)

checkmate generics lifecycleMASSMatrixmethodsnlmeparallelRcpp Rdpackstatsstringr tibble TMButils

LinkingTo (4)

Rcpp RcppEigen testthat TMB

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

12direct

3indirect

junco multipleOutcomes rbmi splinetrials tern.mmrm DoseFinding brms.mmrm broom.helpers clubSandwich crane insight parameters

People & History

People (23)

Maintainer (1)

Daniel Sabanes Bove

Author, Maintainer

Authors (15)

Daniel Sabanes Bove

Author, Maintainer

Julia Dedic

Author

Dan James

Author · added in 0.3.6

Jeremiah Jones

Author · added in 0.3.18

Doug Kelkhoff

Author

Nikolas Ivan Krieger

Author · added in 0.3.15

Kevin Kunzmann

Author

Brian Matthew Lang

Author

Daniel Leibovitz

Author · added in 0.3.6

Liming Li

Author

Arryn Panagos

Author · added in 0.3.18

Jonathan Sidi

Author · added in 0.3.6

Daniel D. Sjoberg

Author · added in 0.3.6

Christian Stock

Author · added in 0.3.6

Ya Wang

Author

Contributors (2)

Craig Gower-Page

Contributor

Lukas A. Widmer

Contributor · added in 0.3.14

Copyright holders (6)

AstraZeneca plc

Copyright holder, Funder · added in 0.3.6

Boehringer Ingelheim Ltd.

Copyright holder, Funder

F. Hoffmann-La Roche AG

Copyright holder, Funder

Gilead Sciences, Inc.

Copyright holder, Funder

Merck Sharp & Dohme, Inc.

Copyright holder, Funder

inferential.biostatistics GmbH

Copyright holder, Funder · added in 0.3.13

Funders (6)

AstraZeneca plc

Copyright holder, Funder · added in 0.3.6

Boehringer Ingelheim Ltd.

Copyright holder, Funder

F. Hoffmann-La Roche AG

Copyright holder, Funder

Gilead Sciences, Inc.

Copyright holder, Funder

Merck Sharp & Dohme, Inc.

Copyright holder, Funder

inferential.biostatistics GmbH

Copyright holder, Funder · added in 0.3.13

Package Timeline

16 releases. Pick two to compare their code metrics. R releases are shown for context.

0.3.18Latest
2026-06-19 · current release · diff ↗
R
R 4.6.0 released · 2026-04-24
0.3.17
2026-01-08 · diff ↗
0.3.16
2025-12-09 · diff ↗
0.3.15
2025-06-10 · diff ↗
R
R 4.5.0 released · 2025-04-11
0.3.14
2024-09-28 · diff ↗
0.3.13
2024-09-23 · diff ↗
0.3.12
2024-06-26 · diff ↗
R
R 4.4.0 released · 2024-04-24
0.3.11
2024-03-05 · diff ↗
0.3.10
2024-01-26 · diff ↗
0.3.9
2024-01-25 · diff ↗
0.3.8
2024-01-24 · diff ↗
0.3.7
2023-12-09 · diff ↗
0.3.6
2023-11-17 · diff ↗

Show 5 earlier events

R
R 4.3.0 released · 2023-04-21
0.2.2
2022-12-20 · diff ↗
0.1.5
2022-10-18 · diff ↗
0.1.3
2022-10-18
R
R 4.2.0 released · 2022-04-22

Package metadata

First published: 2022-10-18
Total releases: 16 / 4 yrs
License: Apache License 2.0 OSI
Minimum R: ≥ 4.1
Bundled data: 126 KB / 3 files
Download size: 912 KB
Installed size: not tracked yet
With dependencies: not tracked yet

Appears in task views

Clinical Trial Design, Monitoring, Analysis and Reporting Mixed, Multilevel, and Hierarchical Models in R

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