DoseFinding

1.4-1

Planning and Analyzing Dose Finding Experiments

11packages depend

76.8Kdownloads / year

84.4%test coverage

8/13checks pass

Overview

About

Maintained by Marius ThomasFirst published 2010-03-0863 releasesCRAN page ↗GitHub ↗

The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) doi:10.1002/sim.6052).

Install

R (CRAN)pak (dev)Ubuntu (r2u)openSUSE (OBS)

install.packages("DoseFinding", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("openpharma/DoseFinding")

Development version from openpharma/DoseFinding. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-dosefinding

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-DoseFinding

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

5NOTE8OK

Failing flavors

NOTE r-devel-linux-x86_64-debian-clang
NOTE r-devel-linux-x86_64-debian-gcc
NOTE r-devel-linux-x86_64-fedora-clang
NOTE r-devel-linux-x86_64-fedora-gcc
NOTE r-devel-windows-x86_64

Slowest check: 15.2 min · r-devel-linux-x86_64-fedora-clang

Check history

NOTE2026-07-16
10 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
OK2026-03-10
14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

Documentation signals are not tracked yet for this package.

Downloads

76.8K

CRAN downloads in the past year

Rank #1,692 · ~210/day · ~6.4K/mo

DoseFinding Releases R versions

Daily download trend is not available in this view yet.

3.5K30 days

15.9K90 days

76.8K1 year

Compare downloads with other packages →

Also on666 r2u30 autocran6.4K conda_forge69 c2d4u

Repository

GitHub ↗ openpharma/dosefinding

14Stars

0Forks

5Open issues

0Open PRs

3Releases

171Commits

7Contributors

171 commits · Last activity 2026-04-14 · 0% stars, 30d

Repository practices

Upstream repositoryBeta

5 development-tooling and community-health practices detected across 4 families in the upstream repository

Checks run against github.com/openpharma/dosefinding on 2026-07-19.

Continuous integration (1)

GitHub Actions

CRAN release process (1)

cran-comments.md

Docs source (1)

README.Rmd

Lint, format, editor (2)

lintrAir

How this is detected·Detection ruleset v1 (2026-07-18)

Dependencies

Declared dependencies

15 external dependencies (excludes base and recommended)

Depends (0)

none

Imports (3)

ggplot2latticemvtnorm

LinkingTo (0)

none

Suggests (16)

emmeans numDeriv Rsolnp quadprogparallelmmrm multcomp knitr rmarkdownMASStestthat tibble RBesTnlmedplyr tidyr

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

11direct

2indirect

MCPModGeneral TestingSimilarity BayesianMCPMod MCPModBC RLoptimal clinDR dosedesignR uniReg MCPModPack TrialSimulator multcomp

Code & Tests

Datasets

People & History

People (7)

Maintainer (1)

Marius Thomas

Author, Maintainer · added in 1.1-1

Authors (6)

Marius Thomas

Author, Maintainer · added in 1.1-1

Author

Author

Author

Author · added in 1.4-1

Ludger Sandig

Author · added in 1.0-1

Novartis Pharma AG

Funders (1)

Novartis Pharma AG

Package Timeline

63 releases. R releases are shown for context.

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R 4.3.0 released · 2023-04-21
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R 4.1.0 released · 2021-05-18
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R 4.0.0 released · 2020-04-24

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R 2.10.0 released · 2009-10-26

Package metadata

First published: 2010-03-08
Total releases: 63 / 16 yrs
License: GPL-3 OSI
Download size: 757 KB
Installed size: not tracked yet
With dependencies: not tracked yet

Appears in task views

Clinical Trial Design, Monitoring, Analysis and Reporting Design of Experiments (DoE) & Analysis of Experimental Data

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