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scCB2

Bioc current

CB2 improves power of cell detection in droplet-based single-cell RNA sequencing data

v1.22.0 · software · GPL-3
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Release Lineage

Entered 3.12 · Oct 28, 2020

Current · Requires R 4.6

1.0 In 12 of 49 releases 3.23

Description

scCB2 is an R package implementing CB2 for distinguishing real cells from empty droplets in droplet-based single cell RNA-seq experiments (especially for 10x Chromium). It is based on clustering similar barcodes and calculating Monte-Carlo p-value for each cluster to test against background distribution. This cluster-level test outperforms single-barcode-level tests in dealing with low count barcodes and homogeneous sequencing library, while keeping FDR well controlled.

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Topics

Software › Infrastructure › DataImport
Software › Technology › Sequencing › RNASeq
Software › Technology › SingleCell
Software › Technology › Sequencing
Software › AssayDomain › GeneExpression
Software › ResearchField › Transcriptomics
Software › WorkflowStep › Preprocessing
Software › StatisticalMethod › Clustering

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