coMethDMR

Description

coMethDMR identifies genomic regions associated with continuous phenotypes by optimally leverages covariations among CpGs within predefined genomic regions. Instead of testing all CpGs within a genomic region, coMethDMR carries out an additional step that selects co-methylated sub-regions first without using any outcome information. Next, coMethDMR tests association between methylation within the sub-region and continuous phenotype using a random coefficient mixed effects model, which models both variations between CpG sites within the region and differential methylation simultaneously.

Code

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Topics

People

• Fernanda Veitzman maintainer
• Lissette Gomez author
• Ning Lijiao contributor
• Boissel Mathilde contributor
• Gabriel Odom author
• Tiago Silva author
• Lily Wang author