ComBatMet

Description

ComBatMet is a regression framework to adjust batch effects in DNA methylation studies. This package includes three batch correction methods. ComBat-met fits beta regression models to the beta-values, calculates batch-free distributions, and maps the quantiles of the estimated distributions to their batch-free counterparts. M-value ComBat log-transforms beta values to M-values prior to applying batch correction via ComBat. ComBat-biseq fits beta-binomial regression models to the bisulfite sequencing data followed by a batch correction procedure similar to ComBat-met.

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People

• Junmin Wang author maintainer