coxme

2.2-22

Mixed Effects Cox Models

24packages depend

219.6Kdownloads / year

68.3%test coverage

13/13checks pass

Overview

About

Maintained by Terry M. TherneauFirst published 2009-09-2019 releasesCRAN page ↗

Fit Cox proportional hazards models containing both fixed and random effects. The random effects can have a general form, of which familial interactions (a "kinship" matrix) is a particular special case. Note that the simplest case of a mixed effects Cox model, i.e. a single random per-group intercept, is also called a "frailty" model. The approach is based on Ripatti and Palmgren, Biometrics 2002.

Install

R (CRAN)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("coxme", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-coxme

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-coxme

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-coxme

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

13OK

Slowest check: 5.6 min · r-devel-linux-x86_64-fedora-clang

Code health

Yes

Tests · ratio 1.68

68.3%

Coverage · measured lines

100%

Documentation · exports

Dependencies · direct

Check history

OK2026-06-09
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-06-08
12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
OK2026-03-10
14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMENoVignettesYes · dynamicpkgdown siteNoNEWSNoCode of conductNoContributing guideNo

Examples that run: 100%
Documented parameters: 73%
Return-value docs: 70%
References docs: 15%

Downloads

219.6K

CRAN downloads in the past year

Rank #974 · ~602/day · ~18.3K/mo

Releases R versions

Daily download trend is not available in this view yet.

12.1K30 days

46.5K90 days

219.6K1 year

Compare downloads with other packages →

Also on553 r2u36 autocran5.7K conda_forge58 c2d4u

Dependencies

Declared dependencies

4 external dependencies (excludes base and recommended)

Depends (4)

R >= 2.10survivalmethodsbdsmatrix

Imports (2)

nlmeMatrix

LinkingTo (1)

bdsmatrix

Suggests (2)

mvtnorm kinship2

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

24direct

1indirect

mlma EQUALSTATS MAGNAMWAR PenCoxFrail bigQF famSKATRC jstable multisite.accuracy svycoxme AICcmodavg amorem car finalfit gap injurytools insight modelbased multcomp parameters remstimate remverse summata tram tramME

Code & Tests

Datasets

People & History

People (1)

Maintainer (1)

Terry M. Therneau

Author, Maintainer

Authors (1)

Terry M. Therneau

Author, Maintainer

Listed in earlier versions (2)

Terry Therneau

no longer listed · 2.0 to 2.2-3

Terry M.

no longer listed · 2.2-4 to 2.2-22

Package Timeline

19 releases. Pick two to compare their code metrics. R releases are shown for context.

R
R 4.6.0 released · 2026-04-24
R
R 4.5.0 released · 2025-04-11
2.2-22Latest
2024-08-23 · current release · diff ↗
R
R 4.4.0 released · 2024-04-24
2.2-20
2024-03-05 · diff ↗
2.2-19
2024-03-02 · diff ↗
R
R 4.3.0 released · 2023-04-21
2.2-18.1
2022-10-03 · diff ↗
2.2-18
2022-09-12 · diff ↗
2.2-17
2022-06-03 · diff ↗
R
R 4.2.0 released · 2022-04-22
R
R 4.1.0 released · 2021-05-18
R
R 4.0.0 released · 2020-04-24
2.2-16
2020-01-14 · diff ↗
2.2-14
2019-07-04 · diff ↗
R
R 3.6.0 released · 2019-04-26

Show 24 earlier events

2.2-10
2018-05-13 · diff ↗
R
R 3.5.0 released · 2018-04-23
2.2-7
2018-01-04 · diff ↗
R
R 3.4.0 released · 2017-04-21
R
R 3.3.0 released · 2016-05-03
2.2-5
2015-06-15 · diff ↗
R
R 3.2.0 released · 2015-04-16
2.2-4
2015-03-03 · diff ↗
R
R 3.1.0 released · 2014-04-10
R
R 3.0.0 released · 2013-04-03
2.2-3
2012-05-15 · diff ↗
2.2-2
2012-04-27 · diff ↗
R
R 2.15.0 released · 2012-03-30
2.2-1
2011-12-30 · diff ↗
R
R 2.14.0 released · 2011-10-31
2.1-3
2011-06-20 · diff ↗
2.1-2
2011-05-24 · diff ↗
2.1-1
2011-05-15 · diff ↗
R
R 2.13.0 released · 2011-04-13
R
R 2.12.0 released · 2010-10-15
R
R 2.11.0 released · 2010-04-22
R
R 2.10.0 released · 2009-10-26
2.0
2009-09-20
R
R 2.9.0 released · 2009-04-17

Package metadata

First published: 2009-09-20
Total releases: 19 / 17 yrs
License: LGPL-2 OSI
Minimum R: ≥ 2.10
Bundled data: 18 KB / 1 file
Download size: 1.0 MB
Installed size: not tracked yet
With dependencies: not tracked yet

Appears in task views

Agricultural Science Mixed, Multilevel, and Hierarchical Models in R Survival Analysis

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