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MethScope

Ultra-Fast Analysis of Sparse DNA Methylome via Recurrent Pattern Encoding

v1.0.1 · Feb 26, 2026 · MIT + file LICENSE

Description

Methods for analyzing DNA methylation data via Most Recurrent Methylation Patterns (MRMPs). Supports cell-type annotation, spatial deconvolution, unsupervised clustering, and cancer cell-of-origin inference. Includes C-backed summaries for YAME “.cg/.cm” files (overlap counts, log2 odds ratios, beta/depth aggregation), an XGBoost classifier, NNLS deconvolution, and plotting utilities. Scales to large spatial and single-cell methylomes and is robust to extreme sparsity.

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r-devel-linux-x86_64-debian-gcc OK
r-devel-linux-x86_64-fedora-clang OK
r-devel-linux-x86_64-fedora-gcc OK
r-devel-macos-arm64 OK
r-devel-windows-x86_64 OK
r-oldrel-macos-arm64 NOTE
r-oldrel-macos-x86_64 NOTE
r-oldrel-windows-x86_64 NOTE
r-patched-linux-x86_64 OK
r-release-linux-x86_64 OK
r-release-macos-arm64 OK
r-release-macos-x86_64 OK
r-release-windows-x86_64 OK
Check details (14 non-OK)
OK r-devel-linux-x86_64-debian-clang

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OK r-devel-linux-x86_64-debian-gcc

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OK r-devel-linux-x86_64-fedora-clang

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OK r-devel-linux-x86_64-fedora-gcc

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OK r-devel-macos-arm64

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OK r-devel-windows-x86_64

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NOTE r-oldrel-macos-arm64

installed package size

  installed size is  8.2Mb
  sub-directories of 1Mb or more:
    R         2.1Mb
    extdata   4.5Mb
    help      1.2Mb
NOTE r-oldrel-macos-x86_64

installed package size

  installed size is  8.3Mb
  sub-directories of 1Mb or more:
    R         2.1Mb
    extdata   4.5Mb
    help      1.2Mb
NOTE r-oldrel-windows-x86_64

installed package size

  installed size is  7.1Mb
  sub-directories of 1Mb or more:
    R         1.1Mb
    extdata   4.5Mb
    help      1.2Mb
OK r-patched-linux-x86_64

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OK r-release-linux-x86_64

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OK r-release-macos-arm64

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OK r-release-macos-x86_64

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OK r-release-windows-x86_64

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Check History

NOTE 11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026
NOTE r-oldrel-macos-arm64

installed package size

  installed size is  8.2Mb
  sub-directories of 1Mb or more:
    R         2.1Mb
    extdata   4.5Mb
    help      1.2Mb
NOTE r-oldrel-macos-x86_64

installed package size

  installed size is  8.3Mb
  sub-directories of 1Mb or more:
    R         2.1Mb
    extdata   4.5Mb
    help      1.2Mb
NOTE r-oldrel-windows-x86_64

installed package size

  installed size is  7.1Mb
  sub-directories of 1Mb or more:
    R         1.1Mb
    extdata   4.5Mb
    help      1.2Mb

Dependency Network

Dependencies Reverse dependencies xgboost dplyr tidyr stringr caret doParallel ggplot2 uwot magrittr FNN data.table nnls MethScope

Version History

new 1.0.1 Mar 9, 2026