orthos
Bioc current`orthos` is an R package for variance decomposition using conditional variational auto-encoders
Release Lineage
Entered 3.18 · Oct 25, 2023
Current · Requires R 4.6
Description
`orthos` decomposes RNA-seq contrasts, for example obtained from a gene knock-out or compound treatment experiment, into unspecific and experiment-specific components. Original and decomposed contrasts can be efficiently queried against a large database of contrasts (derived from ARCHS4, https://maayanlab.cloud/archs4/) to identify similar experiments. `orthos` furthermore provides plotting functions to visualize the results of such a search for similar contrasts.
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Topics
People
- Panagiotis Papasaikas author maintainer
- Friedrich Miescher Institute for Biomedical Research cph
- Charlotte Soneson author
- Michael Stadler author