wnl

0.8.6

Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis

0packages depend

7.1Kdownloads / year

–test coverage

12/13checks pass

Overview

About

Maintained by Kyun-Seop BaeFirst published 2017-10-1623 releasesCRAN page ↗

This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.

Install

R (CRAN)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("wnl", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-wnl

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-wnl

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-wnl

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

1NOTE12OK

Failing flavors

NOTE r-devel-linux-x86_64-debian-gcc

Slowest check: 5.7 min · r-release-macos-x86_64

Code health

None

Tests · ratio 0.00

not tracked

Coverage

Dependencies · direct

Check history

NOTE2026-08-01
12 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
OK2026-03-10
14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMENoVignettesNopkgdown siteNoNEWSNoCode of conductNoContributing guideNo

Examples that run: 100%
Documented parameters: not tracked
Return-value docs: not tracked
References docs: 11%

Downloads

7.1K

CRAN downloads in the past year

Rank #6,145 · ~20/day · ~594/mo

Releases R versions

Daily download trend is not available in this view yet.

29530 days

1.5K90 days

7.1K1 year

Compare downloads with other packages →

Also on113 r2u4 autocran37 c2d4u

Dependencies

Declared dependencies

1 external dependency (excludes base and recommended)

Depends (1)

R >= 3.5.0

Imports (1)

numDeriv

LinkingTo (0)

none

Suggests (0)

none

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

Code & Tests

People & History

People (1)

Maintainer (1)

Kyun-Seop Bae

Author, Maintainer, Copyright holder

Authors (1)

Kyun-Seop Bae

Author, Maintainer, Copyright holder

Kyun-Seop Bae

Author, Maintainer, Copyright holder

Package Timeline

23 releases. Pick two to compare their code metrics. R releases are shown for context.

0.8.6Latest
2026-07-26 · current release · diff ↗
R
R 4.6.0 released · 2026-04-24
0.8.5
2026-03-07 · diff ↗
0.8.4
2025-09-08 · diff ↗
R
R 4.5.0 released · 2025-04-11
0.8.3
2025-03-23 · diff ↗
0.8.2
2025-02-21 · diff ↗
0.8.1
2024-06-01 · diff ↗
R
R 4.4.0 released · 2024-04-24
0.8.0
2024-02-22 · diff ↗
0.7.3
2023-04-25 · diff ↗
R
R 4.3.0 released · 2023-04-21
0.7.2
2023-03-26 · diff ↗
0.7.1
2022-11-30 · diff ↗
0.7.0
2022-10-28 · diff ↗
R
R 4.2.0 released · 2022-04-22

Show 17 earlier events

0.6.4
2021-11-22 · diff ↗
0.6.3
2021-09-06 · diff ↗
0.6.2
2021-08-07 · diff ↗
R
R 4.1.0 released · 2021-05-18
0.6.1
2020-08-27 · diff ↗
0.6.0
2020-07-16 · diff ↗
R
R 4.0.0 released · 2020-04-24
0.5.1
2019-06-10 · diff ↗
0.5.0
2019-05-10 · diff ↗
R
R 3.6.0 released · 2019-04-26
0.4.1
2018-06-14 · diff ↗
R
R 3.5.0 released · 2018-04-23
0.4.0
2018-04-02 · diff ↗
0.3.3
2018-03-02 · diff ↗
0.3.2
2017-12-01 · diff ↗
0.3.1
2017-10-16
R
R 3.4.0 released · 2017-04-21

Package metadata

First published: 2017-10-16
Total releases: 23 / 9 yrs
License: GPL-3 OSI
Minimum R: ≥ 3.5.0
Download size: 108 KB
Installed size: not tracked yet
With dependencies: not tracked yet

Appears in task views

Analysis of Pharmacokinetic Data

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