twoCoprimary

1.0.0

Sample Size and Power Calculation for Two Co-Primary Endpoints

0packages depend

1.3Kdownloads / year

52.8%test coverage

13/13checks pass

Overview

About

Maintained by Gosuke HommaFirst published 2025-11-211 releasesCRAN page ↗GitHub ↗

Comprehensive functions to calculate sample size and power for clinical trials with two co-primary endpoints. The package supports five endpoint combinations: two continuous endpoints (Sozu et al. 2011 doi:10.1080/10543406.2011.551329), two binary endpoints using asymptotic methods (Sozu et al. 2010 doi:10.1002/sim.3972) and exact methods (Homma and Yoshida 2025 doi:10.1177/09622802251368697), mixed continuous and binary endpoints (Sozu et al. 2012 doi:10.1002/bimj.201100221), and mixed count and continuous endpoints (Homma and Yoshida 2024 doi:10.1002/pst.2337). All methods appropriately account for correlation between endpoints and provide both sample size and power calculation capabilities.

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("twoCoprimary", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("gosukehommaEX/twoCoprimary")

Development version from gosukehommaEX/twoCoprimary. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-twocoprimary

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-twoCoprimary

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-twoCoprimary

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

13OK

Slowest check: 7.8 min · r-devel-linux-x86_64-fedora-clang

Code health

Yes

Tests · ratio 0.19

52.8%

Coverage · measured lines

100%

Documentation · exports

Dependencies · direct

Check history

OK2026-03-10
14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMEYes · 480 wordsVignettesYes · dynamicpkgdown siteNoNEWSYes · 67% structuredCode of conductNoContributing guideNo

Examples that run: 96%
Documented parameters: 100%
Return-value docs: 100%
References docs: 65%

Downloads

1.3K

CRAN downloads in the past year

Rank #22,995 · ~4/day · ~111/mo

Releases R versions

Daily download trend is not available in this view yet.

15830 days

49890 days

1.3K1 year

Compare downloads with other packages →

Also on47 r2u26 autocran

Repository

GitHub ↗ gosukehommaex/twocoprimary

0Stars

0Forks

1Open issues

0Open PRs

0Releases

clinical-trialspower-calculationsample-size-calculationco-primary

Last activity 2026-01-01

Repository practices

Upstream repositoryBeta

4 development-tooling and community-health practices detected across 3 families in the upstream repository

Checks run against github.com/gosukehommaex/twocoprimary on 2026-07-19.

Continuous integration (1)

GitHub Actions

CRAN release process (2)

cran-comments.mdCRAN-SUBMISSION

Lint, format, editor (1)

RStudio project

How this is detected·Detection ruleset v1 (2026-07-18)

Dependencies

Declared dependencies

10 external dependencies (excludes base and recommended)

Depends (1)

R >= 3.5.0

Imports (4)

mvtnorm pbivnorm fpComparestats

LinkingTo (0)

none

Suggests (7)

dplyr knitr rmarkdown testthat tibble tidyr readr

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

Code & Tests

People & History

People (1)

Maintainer (1)

Gosuke Homma

Author, Maintainer

Authors (1)

Gosuke Homma

Author, Maintainer

Package Timeline

1 release. R releases are shown for context.

R
R 4.6.0 released · 2026-04-24
1.0.0Latest
2026-03-10 · current release
R
R 4.5.0 released · 2025-04-11

Package metadata

First published: 2025-11-21
Total releases: 1 / 1 yrs
License: MIT + file LICENSE OSI
Minimum R: ≥ 3.5.0
Download size: 221 KB
Installed size: not tracked yet
With dependencies: not tracked yet

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