replicateBE

1.1.3

Average Bioequivalence with Expanding Limits (ABEL)

0packages depend

3.6Kdownloads / year

37.2%test coverage

0/13checks pass

Overview

About

Maintained by Helmut SchützFirst published 2019-06-1413 releasesCRAN page ↗GitHub ↗

Performs comparative bioavailability calculations for Average Bioequivalence with Expanding Limits (ABEL). Implemented are 'Method A' / 'Method B' and the detection of outliers. If the design allows, assessment of the empiric Type I Error and iteratively adjusting alpha to control the consumer risk. Average Bioequivalence - optionally with a tighter (narrow therapeutic index drugs) or wider acceptance range (South Africa: Cmax) - is implemented as well.

Install

R (CRAN)pak (dev)Ubuntu (r2u)openSUSE (OBS)

install.packages("replicateBE", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("Helmut01/replicateBE")

Development version from Helmut01/replicateBE. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-replicatebe

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-replicateBE

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

13NOTE

Failing flavors

NOTE r-devel-linux-x86_64-debian-clang
NOTE r-devel-linux-x86_64-debian-gcc
NOTE r-devel-linux-x86_64-fedora-clang
NOTE r-devel-linux-x86_64-fedora-gcc
NOTE r-devel-windows-x86_64
NOTE r-oldrel-macos-arm64
NOTE r-oldrel-macos-x86_64
NOTE r-oldrel-windows-x86_64
NOTE r-patched-linux-x86_64
NOTE r-release-linux-x86_64
NOTE r-release-macos-arm64
NOTE r-release-macos-x86_64
NOTE r-release-windows-x86_64

Slowest check: 5.4 min · r-devel-linux-x86_64-fedora-clang

Check history

NOTE2026-06-09
0 OK · 13 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-06-08
0 OK · 12 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
NOTE2026-03-10
0 OK · 14 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

Documentation signals are not tracked yet for this package.

Downloads

3.6K

CRAN downloads in the past year

Rank #11,577 · ~10/day · ~302/mo

replicateBE Releases R versions

Daily download trend is not available in this view yet.

30730 days

90090 days

3.6K1 year

Compare downloads with other packages →

Also on95 r2u37 autocran38 c2d4u

Repository

GitHub ↗ helmut01/replicatebe

10Stars

4Forks

3Open issues

0Open PRs

11Releases

357Commits

2Contributors

bioequivalencebiostatisticsrr-packagerstats

357 commits · Last activity 2022-05-04 · +11.1% stars, 30d

Repository practices

Upstream repositoryBeta

1 development-tooling and community-health practice detected across 1 family in the upstream repository

Checks run against github.com/helmut01/replicatebe on 2026-07-19.

Docs source (1)

README.Rmd

How this is detected·Detection ruleset v1 (2026-07-18)

Dependencies

Declared dependencies

8 external dependencies (excludes base and recommended)

Depends (1)

R >= 3.5.0

Imports (7)

readxl PowerTOST lmerTestnlmepbkrtestgraphicsgrDevices

LinkingTo (0)

none

Suggests (4)

knitr rmarkdown testthat devtools

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

Code & Tests

Datasets

People & History

People (3)

Maintainer (1)

Helmut Schütz

Author, Maintainer

Authors (1)

Helmut Schütz

Author, Maintainer

Contributors (2)

Detlew Labes

Contributor

Michael Tomashevskiy

Contributor

Package Timeline

13 releases. R releases are shown for context.

R
R 4.6.0 released · 2026-04-24
R
R 4.5.0 released · 2025-04-11
R
R 4.4.0 released · 2024-04-24
R
R 4.3.0 released · 2023-04-21
1.1.3Latest
2022-05-03 · current release · diff ↗
R
R 4.2.0 released · 2022-04-22
1.1.1
2022-02-13 · diff ↗
1.1.0
2021-06-21 · diff ↗
R
R 4.1.0 released · 2021-05-18
1.0.17
2021-05-14 · diff ↗
1.0.15
2020-07-24 · diff ↗
R
R 4.0.0 released · 2020-04-24
1.0.14
2020-04-09 · diff ↗
1.0.13
2020-01-09 · diff ↗
1.0.12
2019-11-11 · diff ↗
1.0.11
2019-08-25 · diff ↗

Show 5 earlier events

1.0.10
2019-07-24 · diff ↗
1.0.9
2019-07-22 · diff ↗
1.0.8
2019-06-14 · diff ↗
1.0.7
2019-06-14
R
R 3.6.0 released · 2019-04-26

Package metadata

First published: 2019-06-14
Total releases: 13 / 7 yrs
License: GPL (>= 3) OSI
Download size: 291 KB
Installed size: not tracked yet
With dependencies: not tracked yet

Appears in task views

Clinical Trial Design, Monitoring, Analysis and Reporting Analysis of Pharmacokinetic Data

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