mrgsolve

2.0.1

Simulate from ODE-Based Models

12packages depend

39Kdownloads / year

74.2%test coverage

11/13checks pass

Overview

About

Maintained by Kyle T BaronFirst published 2017-03-1131 releasesCRAN page ↗GitHub ↗

Fast simulation from ordinary differential equation (ODE) based models typically employed in quantitative pharmacology and systems biology.

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("mrgsolve", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("metrumresearchgroup/mrgsolve")

Development version from metrumresearchgroup/mrgsolve. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-mrgsolve

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-mrgsolve

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-mrgsolve

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

2NOTE11OK

Failing flavors

NOTE r-devel-linux-x86_64-debian-clang
NOTE r-devel-linux-x86_64-debian-gcc

Slowest check: 8.0 min · r-oldrel-windows-x86_64

Code health

Yes

Tests · ratio 0.55

74.2%

Coverage · measured lines

98%

Documentation · exports

Dependencies · direct

Check history

NOTE2026-07-11
12 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
OK2026-05-02
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
NOTE2026-04-22
12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-04-18
11 OK · 2 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
NOTE2026-03-10
12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMENoVignettesNopkgdown siteNoNEWSYes · 100% structuredCode of conductNoContributing guideNo

Examples that run: 91%
Documented parameters: 99%
Return-value docs: 52%
References docs: 1%

Downloads

39K

CRAN downloads in the past year

Rank #2,912 · ~107/day · ~3.2K/mo

Releases R versions

Daily download trend is not available in this view yet.

1.7K30 days

5.5K90 days

39K1 year

Compare downloads with other packages →

Also on613 r2u36 autocran6.6K conda_forge76 c2d4u

Repository

GitHub ↗ metrumresearchgroup/mrgsolve

166Stars

38Forks

93Open issues

1Open PRs

63Releases

3,846Commits

10Contributors

odermrgsolverstats

License GPL-2.0 · 3,846 commits · Last activity 2026-06-26 · +1.8% stars, 30d

Stars over time

2025-05-12 · 1382026-07-17 · 166

Repository practices

Upstream repositoryBeta

4 development-tooling and community-health practices detected across 4 families in the upstream repository

Checks run against github.com/metrumresearchgroup/mrgsolve on 2026-07-19.

Continuous integration (1)

GitHub Actions

Reproducibility and dev environment (1)

Makefile

Docs source (1)

README.Rmd

Lint, format, editor (1)

RStudio project

How this is detected·Detection ruleset v1 (2026-07-18)

Dependencies

Declared dependencies

19 external dependencies (excludes base and recommended)

Depends (2)

R >= 4.1.0methods

Imports (8)

Rcpp dplyr magrittr tibble rlang tidyselect lifecycle glue

LinkingTo (3)

Rcpp RcppArmadillo BH (>= 1.75.0-0)

Suggests (9)

rstudioapilatticetestthat xml2 rmarkdown yaml knitr data.table pmxTools

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

12direct

0indirect

mrgsim.parallel mrgsim.sa exeval mapbayr simtte PopED amp.sim campsis coveffectsplot rxode2mrgsolvebridge tci vachette

Code & Tests

Code Composition

R 23,096 (60%)Rd 6,800 (18%)C++ 6,078 (16%)C 1,734 (4%)Other 974 (3%)

Code characteristics

Object systems

S374S4 class12S4 generic26S4 method128

Cyclomatic complexity: 2.0 median / 31 max
Test cases: 493 / 0.55 per code line

Test coverage

Line coverage

74%

Expression

73.9%

Tests / Examples

74.2% / 58% ex

Functions

729 107 exported

Complexity

2.7 avg / 31 max

Call network

729 nodes / 823 edges

Call graph

Open call graph →

Loading call graph…

Lowest coverage

729 functions

Function	Cyclo	Coverage
as.tbl.mrgsims exp	1	0%
as_cmat exp	1	0%
as_data_frame.mrgsims exp	1	0%
assign_ev exp	1	0%
carry.out exp	1	0%
file_show exp	3	0%

Datasets

Bundled datasets · 5

Name	Class	Rows × Cols	Also ships in
exBoot	data.frame	100 × 13	–
exidata	data.frame	10 × 7	–
extran1	data.frame	9 × 8	–
extran2	data.frame	714 × 8	–
extran3	data.frame	714 × 11	–

People & History

People (10)

Maintainer (1)

Kyle T Baron

Author, Maintainer

Authors (1)

Kyle T Baron

Author, Maintainer

Contributors (8)

Bill Denney

Contributor · added in 0.9.0

Bill Gillespie

Contributor

Felicien Le Louedec

Contributor · added in 0.10.7

Charles Margossian

Contributor

Kyle Meyer

Contributor · added in 1.1.1

Devin Pastoor

Contributor

Dilawar Singh

Contributor · added in 0.10.0

Timothy Waterhouse

Contributor · added in 0.11.0

Metrum Research Group

Listed in earlier versions (4)

Metrum Research Group LLC

no longer listed · 0.8.2 to 0.8.12

Alan C Hindmarsh

no longer listed · 0.8.2 to 0.9.2

Linda R Petzold

no longer listed · 0.8.2 to 0.9.2

odepack authors

no longer listed · 0.9.1 to 0.9.2

Package Timeline

31 releases. Pick two to compare their code metrics. R releases are shown for context.

2.0.1Latest
2026-05-20 · current release · diff ↗
R
R 4.6.0 released · 2026-04-24
1.7.2
2026-01-22 · diff ↗
1.6.1
2025-08-22 · diff ↗
R
R 4.5.0 released · 2025-04-11
1.5.2
2024-10-18 · diff ↗
1.5.1
2024-07-26 · diff ↗
R
R 4.4.0 released · 2024-04-24
1.4.1
2024-02-14 · diff ↗
1.4.0
2024-02-08 · diff ↗
1.3.0
2023-12-04 · diff ↗
1.1.1
2023-08-16 · diff ↗
R
R 4.3.0 released · 2023-04-21
1.0.9
2023-03-10 · diff ↗
1.0.8
2023-03-04 · diff ↗
1.0.6
2022-08-29 · diff ↗

Show 28 earlier events

1.0.4
2022-05-16 · diff ↗
R
R 4.2.0 released · 2022-04-22
1.0.3
2022-03-21 · diff ↗
1.0.2
2022-03-17 · diff ↗
1.0.0
2022-01-20 · diff ↗
R
R 4.1.0 released · 2021-05-18
0.11.1
2021-05-10 · diff ↗
0.11.0
2021-03-28 · diff ↗
0.10.7
2020-12-09 · diff ↗
0.10.4
2020-06-19 · diff ↗
R
R 4.0.0 released · 2020-04-24
0.10.1
2020-02-21 · diff ↗
0.10.0
2019-10-15 · diff ↗
0.9.2
2019-07-14 · diff ↗
unarchivedReturned to CRAN
2019-07-14
archivedRemoved from CRAN
2019-07-03
check issues were not corrected in time LTO mismatches in common blocks
0.9.1
2019-06-15 · diff ↗
R
R 3.6.0 released · 2019-04-26
0.9.0
2019-01-23 · diff ↗
0.8.12
2018-04-27 · diff ↗
0.8.11
2018-04-26 · diff ↗
R
R 3.5.0 released · 2018-04-23
0.8.10
2017-11-01 · diff ↗
0.8.9
2017-08-28 · diff ↗
R
R 3.4.0 released · 2017-04-21
0.8.6
2017-03-16 · diff ↗
0.8.2
2017-03-11
R
R 3.3.0 released · 2016-05-03

Package metadata

First published: 2017-03-11
Total releases: 31 / 9 yrs
License: GPL (>= 2) OSI
Minimum R: ≥ 4.1.0
Bundled data: 11 KB / 6 files
Download size: 497 KB
Installed size: not tracked yet
With dependencies: not tracked yet

Appears in task views

Differential Equations Mixed, Multilevel, and Hierarchical Models in R Analysis of Pharmacokinetic Data

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