invivoPKfit

2.0.2

Fits Toxicokinetic Models to In Vivo PK Data Sets

0packages depend

2.2Kdownloads / year

66.7%test coverage

13/13checks pass

Overview

About

Maintained by John WambaughFirst published 2025-01-093 releasesCRAN page ↗

Takes in vivo toxicokinetic concentration-time data and fits parameters of 1-compartment and 2-compartment models for each chemical. These methods are described in detail in "Informatics for Toxicokinetics" (2025).

Install

R (CRAN)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("invivoPKfit", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-invivopkfit

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-invivoPKfit

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-invivoPKfit

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

13OK

Slowest check: 14.5 min · r-devel-linux-x86_64-fedora-clang

Code health

Yes

Tests · ratio 0.04

66.7%

Coverage · measured lines

100%

Documentation · exports

Dependencies · direct

Check history

OK2026-03-10
14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMEYes · 576 wordsVignettesYes · dynamicpkgdown siteNoNEWSYes · 100% structuredCode of conductNoContributing guideNo

Examples that run: not tracked
Documented parameters: 97%
Return-value docs: 100%
References docs: 2%

Downloads

2.2K

CRAN downloads in the past year

Rank #21,202 · ~6/day · ~183/mo

Releases R versions

Daily download trend is not available in this view yet.

16930 days

57190 days

2.2K1 year

Compare downloads with other packages →

Also on130 r2u20 autocran

Dependencies

Declared dependencies

22 external dependencies (excludes base and recommended)

Depends (1)

R >= 4.1.0

Imports (17)

cli dplyr ggplot2 httkMASSMatrixmirai numDeriv optimx PK pracma purrr rlangstatsscales tibble tidyr

LinkingTo (0)

none

Suggests (8)

cowplot knitr RColorBrewer rmarkdown stringr testthat glue tidyverse

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

Code & Tests

Datasets

People & History

People (4)

Maintainer (1)

John Wambaugh

Author, Maintainer

Authors (4)

John Wambaugh

Author, Maintainer

Chris Cook

Author

Gilberto Padilla Mercado

Author

Caroline Ring

Author

Package Timeline

3 releases. Pick two to compare their code metrics. R releases are shown for context.

R
R 4.6.0 released · 2026-04-24
2.0.2Latest
2025-08-26 · current release · diff ↗
R
R 4.5.0 released · 2025-04-11
2.0.1
2025-03-24 · diff ↗
2.0.0
2025-01-09
R
R 4.4.0 released · 2024-04-24

Package metadata

First published: 2025-01-09
Total releases: 3 / 1 yrs
License: GPL-3 OSI
Minimum R: ≥ 4.1.0
Bundled data: 1.2 MB / 16 files
Download size: 1.7 MB
Installed size: not tracked yet
With dependencies: not tracked yet

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