esDesign
Adaptive Enrichment Designs with Sample Size Re-Estimation
Description
Software of 'esDesign' is developed to implement the adaptive enrichment designs with sample size re-estimation presented in Lin et al. (2021) <doi: 10.1016/j.cct.2020.106216>. In details, three-proposed trial designs are provided, including the AED1-SSR (or ES1-SSR), AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition, this package also contains several widely used adaptive designs, such as the Marker Sequential Test (MaST) design proposed Freidlin et al. (2014) <doi:10.1177/1740774513503739>, the adaptive enrichment designs without early stopping (AED or ES), the sample size re-estimation procedure (SSR) based on the conditional power proposed by Proschan and Hunsberger (1995), and some useful functions. In details, we can calculate the futility and/or efficacy stopping boundaries, the sample size required, calibrate the value of the threshold of the difference between subgroup-specific test statistics, conduct the simulation studies in AED, SSR, AED1-SSR, AED2-SSR and AED3-SSR.
Downloads
314
Last 30 days
12602nd
795
Last 90 days
2.7K
Last year
Trend: +13.8% (30d vs prior 30d)
CRAN Check Status
Show all 14 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (2 non-OK)
CRAN incoming feasibility
Maintainer: ‘Zhao Yang <yangz98@connect.hku.hk>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Zhao",
family = "Yang",
role = c("aut", "cre"),
email = "yangz98@connect.hku.hk"),
person(given = "Ruitao",
family = "Lin",
role = "aut"),
person(given = "Guosheng",
family = "Yin",
role = "aut"),
person(given = "Ying",
family = "Yuan",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Zhao Yang <yangz98@connect.hku.hk>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Zhao",
family = "Yang",
role = c("aut", "cre"),
email = "yangz98@connect.hku.hk"),
person(given = "Ruitao",
family = "Lin",
role = "aut"),
person(given = "Guosheng",
family = "Yin",
role = "aut"),
person(given = "Ying",
family = "Yuan",
role = "aut"))
as necessary.
Check History
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
CRAN incoming feasibility
Maintainer: ‘Zhao Yang <yangz98@connect.hku.hk>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Zhao",
family = "Yang",
role = c("aut", "cre"),
...[truncated]...
ut"),
person(given = "Guosheng",
family = "Yin",
role = "aut"),
person(given = "Ying",
family = "Yuan",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Zhao Yang <yangz98@connect.hku.hk>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Zhao",
family = "Yang",
role = c("aut", "cre"),
...[truncated]...
ut"),
person(given = "Guosheng",
family = "Yin",
role = "aut"),
person(given = "Ying",
family = "Yuan",
role = "aut"))
as necessary.