bhmbasket
1.1.0Bayesian Hierarchical Models for Basket Trials
Overview
Provides functions for the evaluation of basket trial designs with binary endpoints. Operating characteristics of a basket trial design are assessed by simulating trial data according to scenarios, analyzing the data with Bayesian hierarchical models (BHMs), and assessing decision probabilities on stratum and trial-level based on Go / No-go decision making. The package is build for high flexibility regarding decision rules, number of interim analyses, number of strata, and recruitment. The BHMs proposed by Berry et al. (2013) doi:10.1177/1740774513497539 and Neuenschwander et al. (2016) doi:10.1002/pst.1730, as well as a model that combines both approaches are implemented. Functions are provided to implement Bayesian decision rules as for example proposed by Fisch et al. (2015) doi:10.1177/2168479014533970. In addition, posterior point estimates (mean/median) and credible intervals for response rates and some model parameters can be calculated. For simulated trial data, bias and mean squared errors of posterior point estimates for response rates can be provided.
Install
Health
- OK2026-03-1014 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
Documentation
- Examples that run
- 100%
- Documented parameters
- 99%
- Return-value docs
- 100%
- References docs
- 28%
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Checks run against github.com/boehringer-ingelheim/bhmbasket on 2026-07-30.
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Code & Tests
People & History
7 releases. Pick two to compare their code metrics. R releases are shown for context.
- RR 4.6.0 released · 2026-04-24
- 1.1.0Latest
- 1.0.02026-02-21 · diff ↗
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- 0.9.52022-02-14 · diff ↗
- 0.9.42022-01-18 · diff ↗
- 0.9.32021-10-11 · diff ↗
- RR 4.1.0 released · 2021-05-18
- 0.9.22021-04-07 · diff ↗
- 0.9.12021-02-15
- RR 4.0.0 released · 2020-04-24
Package metadata
- First published
- 2021-02-15
- Total releases
- 7 / 5 yrs
- License
- GPL-3 OSI
- Minimum R
- ≥ 3.6.0
- Download size
- 651 KB
- Installed size
- not tracked yet
- With dependencies
- not tracked yet