RefBasedMI

0.2.0

Reference-Based Imputation for Longitudinal Clinical Trials with Protocol Deviation

0packages depend

3.1Kdownloads / year

–test coverage

13/13checks pass

Overview

About

Maintained by Matteo QuartagnoFirst published 2023-04-273 releasesCRAN page ↗GitHub ↗

Imputation of missing numerical outcomes for a longitudinal trial with protocol deviations. The package uses distinct treatment arm-based assumptions for the unobserved data, following the general algorithm of Carpenter, Roger, and Kenward (2013) doi:10.1080/10543406.2013.834911, and the causal model of White, Royes and Best (2020) doi:10.1080/10543406.2019.1684308. Sensitivity analyses to departures from these assumptions can be done by the Delta method of Roger. The program uses the same algorithm as the 'mimix' 'Stata' package written by Suzie Cro, with additional coding for the causal model and delta method. The reference-based methods are jump to reference (J2R), copy increments in reference (CIR), copy reference (CR), and the causal model, all of which must specify the reference treatment arm. Other methods are missing at random (MAR) and the last mean carried forward (LMCF). Individual-specific imputation methods (and their reference groups) can be specified.

Install

R (CRAN)pak (dev)Ubuntu (r2u)openSUSE (OBS)

install.packages("RefBasedMI", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("UCL/RefBasedMI")

Development version from UCL/RefBasedMI. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-refbasedmi

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-RefBasedMI

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

13OK

Slowest check: 3.4 min · r-devel-linux-x86_64-fedora-clang

Check history

OK2026-06-09
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-06-08
12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
OK2026-05-02
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-04-25
11 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
OK2026-03-10
14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

Documentation signals are not tracked yet for this package.

Downloads

3.1K

CRAN downloads in the past year

Rank #14,987 · ~9/day · ~262/mo

RefBasedMI Releases R versions

Daily download trend is not available in this view yet.

22330 days

72390 days

3.1K1 year

Compare downloads with other packages →

Also on396 r2u32 autocran

Repository

GitHub ↗ ucl/refbasedmi

5Stars

4Forks

3Open issues

0Open PRs

1Releases

590Commits

5Contributors

License GPL-3.0 · 590 commits · Last activity 2024-09-04 · 0% stars, 30d

Repository practices

Upstream repositoryBeta

Checks run against github.com/ucl/refbasedmi on 2026-07-19.

No development-tooling practices detected in the upstream repository.

How this is detected·Detection ruleset v1 (2026-07-18)

Dependencies

Declared dependencies

5 external dependencies (excludes base and recommended)

Depends (1)

R >= 3.5.0

Imports (5)

data.table Hmisc mice pastecs assertthat

LinkingTo (0)

none

Suggests (0)

none

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

Code & Tests

Datasets

People & History

People (2)

Maintainer (1)

Matteo Quartagno

Maintainer · added in 0.2.0

Authors (1)

Kevin McGrath

Author

Listed in earlier versions (1)

Ian White

no longer listed · 0.1.1

Package Timeline

3 releases. R releases are shown for context.

R
R 4.6.0 released · 2026-04-24
R
R 4.5.0 released · 2025-04-11
0.2.0Latest
2024-09-09 · current release · diff ↗
unarchivedReturned to CRAN
2024-09-09
R
R 4.4.0 released · 2024-04-24
archivedRemoved from CRAN
2023-08-25
requires archived package 'norm2'
0.1.1
2023-08-21 · diff ↗
0.1.0
2023-04-27
R
R 4.3.0 released · 2023-04-21

Package metadata

First published: 2023-04-27
Total releases: 3 / 3 yrs
License: GPL-3 OSI
Download size: 495 KB
Installed size: not tracked yet
With dependencies: not tracked yet

Report a problem with this page →