Keyboard
Bayesian Designs for Early Phase Clinical Trials
Description
We developed a package 'Keyboard' for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The 'Keyboard' designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) <doi:10.1158/1078-0432.CCR-17-0220>, Li DH, Whitmore JB, Guo W, Ji Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>, Liu S, Johnson VE (2016) <doi:10.1093/biostatistics/kxv040>, Zhou Y, Lee JJ, Yuan Y (2019) <doi:10.1002/sim.8475>, Pan H, Lin R, Yuan Y (2020) <doi:10.1016/j.cct.2020.105972>). The 'Keyboard' package provides tools for designing, conducting, and analyzing single-agent, drug-combination, and phase I/II dose-finding clinical trials. For more details about how to use this packge, please refer to Li C, Sun H, Cheng C, Tang L, and Pan H. (2022) "A software tool for both the maximum tolerated dose and the optimal biological dose finding trials in early phase designs". Manuscript submitted for publication.
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CRAN Check Status
Show all 14 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (14 non-OK)
CRAN incoming feasibility
Maintainer: ‘Xiaomeng Yuan <xiaomeng.yuan@stjude.org>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xiaomeng",
family = "Yuan",
role = c("aut", "cre"),
email = "xiaomeng.yuan@stjude.org"),
person(given = "Chen",
family = "Li",
role = "aut"),
person(given = "Hongying",
family = "Sun",
role = "aut"),
person(given = "Li",
family = "Tang",
role = "aut"),
person(given = "Haitao",
family = "Pan",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Xiaomeng Yuan <xiaomeng.yuan@stjude.org>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xiaomeng",
family = "Yuan",
role = c("aut", "cre"),
email = "xiaomeng.yuan@stjude.org"),
person(given = "Chen",
family = "Li",
role = "aut"),
person(given = "Hongying",
family = "Sun",
role = "aut"),
person(given = "Li",
family = "Tang",
role = "aut"),
person(given = "Haitao",
family = "Pan",
role = "aut"))
as necessary.
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Check History
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026
CRAN incoming feasibility
Maintainer: ‘Xiaomeng Yuan <xiaomeng.yuan@stjude.org>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xiaomeng",
family = "Yuan",
role = c("aut", "cre"),
email = "xiaomeng.yuan@stjude.org"),
person(given = "Chen",
family = "Li",
role = "aut"),
person(given = "Hongying",
family = "Sun",
CRAN incoming feasibility
Maintainer: ‘Xiaomeng Yuan <xiaomeng.yuan@stjude.org>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Xiaomeng",
family = "Yuan",
role = c("aut", "cre"),
email = "xiaomeng.yuan@stjude.org"),
person(given = "Chen",
family = "Li",
role = "aut"),
person(given = "Hongying",
family = "Sun",