GRAB

0.2.5

Genome-Wide Robust Analysis for Biobank Data (GRAB)

0packages depend

4.7Kdownloads / year

–test coverage

13/13checks pass

Overview

About

Maintained by Woody MiaoFirst published 2025-07-255 releasesCRAN page ↗

Provides a comprehensive suite of genome-wide association study (GWAS) methods specifically designed for biobank-scale data, including but not limited to, robust approaches for time-to-event traits (Li et al., 2025 doi:10.1038/s43588-025-00864-z) and ordinal categorical traits (Bi et al., 2021 doi:10.1016/j.ajhg.2021.03.019). The package also offers general frameworks for GWAS of any trait type (Bi et al., 2020 doi:10.1016/j.ajhg.2020.06.003), while accounting for sample relatedness (Xu et al., 2025 doi:10.1038/s41467-025-56669-1) or population structure (Ma et al., 2025 doi:10.1186/s13059-025-03827-9). By accurately approximating score statistic distributions using saddlepoint approximation (SPA), these methods can effectively control type I error rates for rare variants and in the presence of unbalanced phenotype distributions. Additionally, the package includes functions for simulating genotype and phenotype data to support research and method development.

Install

R (CRAN)Ubuntu (r2u)Fedora (COPR)

install.packages("GRAB", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-grab

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-GRAB

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

Health

CRAN checks

13OK

Slowest check: 7.1 min · r-oldrel-windows-x86_64

Code health

None

Tests · ratio 0.00

not tracked

Coverage

100%

Documentation · exports

Dependencies · direct

Check history

OK2026-06-09
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-06-08
12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
OK2026-05-02
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
NOTE2026-04-22
12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-04-18
11 OK · 2 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE

Show 1 earlier snapshots

NOTE2026-03-10
12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMEYes · 135 wordsVignettesNopkgdown siteNoNEWSNoCode of conductNoContributing guideNo

Examples that run: 100%
Documented parameters: 88%
Return-value docs: 100%
References docs: 25%

Downloads

4.7K

CRAN downloads in the past year

Rank #12,296 · ~13/day · ~395/mo

Releases R versions

Daily download trend is not available in this view yet.

41530 days

86890 days

4.7K1 year

Compare downloads with other packages →

Also on421 r2u2.6K conda_forge

Dependencies

Declared dependencies

18 external dependencies (excludes base and recommended)

Depends (1)

R >= 3.5.0

Imports (12)

dplyr data.table mvtnormMatrixRSQLite lme4 ordinalsurvivalRcpp RcppParallel igraph rlang

LinkingTo (4)

Rcpp RcppArmadillo RcppParallel BH

Suggests (4)

SKAT dbplyr tidyr R.utils

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

Code & Tests

People & History

People (6)

Maintainer (1)

Woody Miao

Maintainer

Authors (5)

Author

Author

Author

Author

Author

Package Timeline

5 releases. Pick two to compare their code metrics. R releases are shown for context.

0.2.5Latest
2026-07-03 · current release · diff ↗
R
R 4.6.0 released · 2026-04-24
0.2.4
2025-12-05 · diff ↗
0.2.3
2025-08-20 · diff ↗
0.2.2
2025-07-29 · diff ↗
0.2.1
2025-07-25
R
R 4.5.0 released · 2025-04-11

Package metadata

First published: 2025-07-25
Total releases: 5 / 1 yrs
License: GPL (>= 2) OSI
Minimum R: ≥ 3.5.0
Download size: 1.7 MB
Installed size: not tracked yet
With dependencies: not tracked yet

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