BOP2FE

1.0.3

Bayesian Optimal Phase II Design with Futility and Efficacy Stopping Boundaries

1packages depend

2.1Kdownloads / year

12.9%test coverage

13/13checks pass

Overview

About

Maintained by Belay Birlie YimerFirst published 2025-09-291 releasesCRAN page ↗GitHub ↗

Bayesian optimal design with futility and efficacy stopping boundaries (BOP2-FE) is a novel statistical framework for single-arm Phase II clinical trials. It enables early termination for efficacy when interim data are promising, while explicitly controlling Type I and Type II error rates. The design supports a variety of endpoint structures, including single binary endpoints, nested endpoints, co-primary endpoints, and joint monitoring of efficacy and toxicity. The package provides tools for enumerating stopping boundaries prior to trial initiation and for conducting simulation studies to evaluate the design’s operating characteristics. Users can flexibly specify design parameters to suit their specific applications. For methodological details, refer to Xu et al. (2025) doi:10.1080/10543406.2025.2558142.

Install

R (CRAN)pak (dev)Ubuntu (r2u)openSUSE (OBS)

install.packages("BOP2FE", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("belayb/BOP2FE")

Development version from belayb/BOP2FE. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-bop2fe

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-BOP2FE

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

13OK

Slowest check: 3.1 min · r-devel-linux-x86_64-fedora-clang

Check history

OK2026-03-10
14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

Documentation signals are not tracked yet for this package.

Downloads

2.1K

CRAN downloads in the past year

Rank #16,978 · ~6/day · ~172/mo

BOP2FE Releases R versions

Daily download trend is not available in this view yet.

22630 days

66090 days

2.1K1 year

Compare downloads with other packages →

Also on70 r2u77 autocran

Repository

GitHub ↗ belayb/bop2fe

2Stars

1Forks

0Open issues

0Open PRs

1Releases

54Commits

1Contributors

54 commits · Last activity 2025-10-01 · 0% stars, 30d

Repository practices

Upstream repositoryBeta

4 development-tooling and community-health practices detected across 4 families in the upstream repository

Checks run against github.com/belayb/bop2fe on 2026-07-19.

Continuous integration (1)

GitHub Actions

CRAN release process (1)

cran-comments.md

Docs source (1)

README.Rmd

Lint, format, editor (1)

RStudio project

How this is detected·Detection ruleset v1 (2026-07-18)

Dependencies

Declared dependencies

4 external dependencies (excludes base and recommended)

Depends (0)

none

Imports (5)

gridExtra patchwork ggplot2statsutils

LinkingTo (0)

none

Suggests (1)

spelling

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

1direct

0indirect

bfboinet

Code & Tests

People & History

People (5)

Maintainer (1)

Belay Birlie Yimer

Author, Maintainer

Authors (5)

Author, Maintainer

Author

Author

Author

Author

Package Timeline

1 release. R releases are shown for context.

R
R 4.6.0 released · 2026-04-24
1.0.3Latest
2026-03-10 · current release
R
R 4.5.0 released · 2025-04-11

Package metadata

First published: 2025-09-29
Total releases: 1 / 1 yrs
License: MIT + file LICENSE OSI
Download size: 436 KB
Installed size: not tracked yet
With dependencies: not tracked yet

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