bcSeq

Description

This Rcpp-based package implements a highly efficient data structure and algorithm for performing alignment of short reads from CRISPR or shRNA screens to reference barcode library. Sequencing error are considered and matching qualities are evaluated based on Phred scores. A Bayes' classifier is employed to predict the originating barcode of a read. The package supports provision of user-defined probability models for evaluating matching qualities. The package also supports multi-threading.

Code

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Topics

People

• Jiaxing Lin author maintainer
• Andrew Allen contributor
• James Alvarez contributor
• Cliburn Chan contributor
• Jeffrey S. Damrauer contributor
• Scott Floyd contributor
• Joshua Granek contributor
• Jeremy Gresham author
• So Young Kim contributor
• Kouros Owzar author
• Tongrong Wang contributor
• Jichun Xie author