pssmooth

Description

Implements estimation and testing procedures for evaluating an intermediate biomarker response as a principal surrogate of a clinical response to treatment (i.e., principal stratification effect modification analysis), as described in Juraska M, Huang Y, and Gilbert PB (2020), Inference on treatment effect modification by biomarker response in a three-phase sampling design, Biostatistics, 21(3): 545-560 <doi:10.1093/biostatistics/kxy074>. The methods avoid the restrictive 'placebo structural risk' modeling assumption common to past methods and further improve robustness by the use of nonparametric kernel smoothing for biomarker density estimation. A randomized controlled two-group clinical efficacy trial is assumed with an ordered categorical or continuous univariate biomarker response measured at a fixed timepoint post-randomization and with a univariate baseline surrogate measure allowed to be observed in only a subset of trial participants with an observed biomarker response (see the flexible three-phase sampling design in the paper for details). Bootstrap-based procedures are available for pointwise and simultaneous confidence intervals and testing of four relevant hypotheses. Summary and plotting functions are provided for estimation results.

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Maintainer: ‘Michal Juraska <mjuraska@fredhutch.org>’

Package CITATION file contains call(s) to old-style citEntry().  Please
use bibentry() instead.

Found the following URLs which should use \doi (with the DOI name only):
  File ‘riskCurve.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘summary.riskCurve.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘testConstancy.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘testEquality.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074

Maintainer: ‘Michal Juraska <mjuraska@fredhutch.org>’

Package CITATION file contains call(s) to old-style citEntry().  Please
use bibentry() instead.

Found the following URLs which should use \doi (with the DOI name only):
  File ‘riskCurve.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘summary.riskCurve.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘testConstancy.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘testEquality.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074

  'LazyData' is specified without a 'data' directory

  'LazyData' is specified without a 'data' directory

  'LazyData' is specified without a 'data' directory

Check History

Maintainer: ‘Michal Juraska <mjuraska@fredhutch.org>’

Package CITATION file contains call(s) to old-style citEntry().  Please
use bibentry() instead.

Found the following URLs which should use \doi (with the DOI name only):
  File ‘riskCurve.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘summary.riskCurve.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘testConstancy.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘testEquality.Rd’:
    https://doi.org/1

Maintainer: ‘Michal Juraska <mjuraska@fredhutch.org>’

Package CITATION file contains call(s) to old-style citEntry().  Please
use bibentry() instead.

Found the following URLs which should use \doi (with the DOI name only):
  File ‘riskCurve.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘summary.riskCurve.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘testConstancy.Rd’:
    https://doi.org/10.1093/biostatistics/kxy074
  File ‘testEquality.Rd’:
    https://doi.org/1

  'LazyData' is specified without a 'data' directory

  'LazyData' is specified without a 'data' directory

  'LazyData' is specified without a 'data' directory

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