pocrm

Dose Finding in Drug Combination Phase I Trials Using PO-CRM

v0.13 · Sep 8, 2021 · GPL-2

Description

Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

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CRAN Check Status

2 NOTE

12 OK

Show all 14 flavors

Flavor	Status	Time
r-devel-linux-x86_64-debian-clang	NOTE	21.9s
r-devel-linux-x86_64-debian-gcc	NOTE	17.6s
r-devel-linux-x86_64-fedora-clang	OK	33.1s
r-devel-linux-x86_64-fedora-gcc	OK	31.1s
r-devel-macos-arm64	OK	11s
r-devel-windows-x86_64	OK	42s
r-oldrel-macos-arm64	OK
r-oldrel-macos-x86_64	OK	20s
r-oldrel-windows-x86_64	OK	47s
r-patched-linux-x86_64	OK	19.7s
r-release-linux-x86_64	OK	19.5s
r-release-macos-arm64	OK
r-release-macos-x86_64	OK	23s
r-release-windows-x86_64	OK	43s

Check details (14 non-OK)

NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘"Brewer, Ben (arb5mt)" <arb5mt@virginia.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = c("Nolan", "A."),
                      family = "Wages",
                      role = "aut"),
               person(family = "\"Brewer",
                      role = "cre"),
               person(family = "Ben\"",
                      role = "cre",
                      email = "arb5mt@virginia.edu",
                      comment = "arb5mt"))
as necessary.

NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘"Brewer, Ben (arb5mt)" <arb5mt@virginia.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = c("Nolan", "A."),
                      family = "Wages",
                      role = "aut"),
               person(family = "\"Brewer",
                      role = "cre"),
               person(family = "Ben\"",
                      role = "cre",
                      email = "arb5mt@virginia.edu",
                      comment = "arb5mt"))
as necessary.

OK r-devel-linux-x86_64-fedora-clang

OK r-devel-linux-x86_64-fedora-gcc

OK r-devel-macos-arm64

OK r-devel-windows-x86_64

OK r-oldrel-macos-arm64

OK r-oldrel-macos-x86_64

OK r-oldrel-windows-x86_64

OK r-patched-linux-x86_64

OK r-release-linux-x86_64

OK r-release-macos-arm64

OK r-release-macos-x86_64

OK r-release-windows-x86_64

Check History

NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026

NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘"Brewer, Ben (arb5mt)" <arb5mt@virginia.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = c("Nolan", "A."),
                      family = "Wages",
                      role = "aut"),
               person(family = "\"Brewer",
                      role = "cre"),
               person(family = "Ben\"",
                      role = "cre",
                      email = "arb5mt@virginia.edu",
                      comment = "arb5mt"))
as

NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘"Brewer, Ben (arb5mt)" <arb5mt@virginia.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = c("Nolan", "A."),
                      family = "Wages",
                      role = "aut"),
               person(family = "\"Brewer",
                      role = "cre"),
               person(family = "Ben\"",
                      role = "cre",
                      email = "arb5mt@virginia.edu",
                      comment = "arb5mt"))
as

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Version History

new 0.13 Mar 10, 2026