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Negative Binomial Mixed Models Using Large-Sample Approximation for Differential Expression Analysis of ScRNA-Seq Data

v1.5.6 · Dec 6, 2025 · GPL-3

Description

A fast negative binomial mixed model for conducting association analysis of multi-subject single-cell data. It can be used for identifying marker genes, differential expression and co-expression analyses. The model includes subject-level random effects to account for the hierarchical structure in multi-subject single-cell data. See He et al. (2021) <doi:10.1038/s42003-021-02146-6>.

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ERROR r-devel-linux-x86_64-debian-clang

package dependencies

Package required but not available: ‘SingleCellExperiment’

See section ‘The DESCRIPTION file’ in the ‘Writing R Extensions’
manual.
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NOTE r-oldrel-macos-arm64

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  installed size is 29.4Mb
  sub-directories of 1Mb or more:
    libs  27.8Mb
NOTE r-oldrel-macos-x86_64

installed package size

  installed size is 31.0Mb
  sub-directories of 1Mb or more:
    libs  29.3Mb
OK r-oldrel-windows-x86_64

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OK r-release-linux-x86_64

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Check History

ERROR 11 OK · 2 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Mar 9, 2026
ERROR r-devel-linux-x86_64-debian-clang

package dependencies

Package required but not available: ‘SingleCellExperiment’

See section ‘The DESCRIPTION file’ in the ‘Writing R Extensions’
manual.
NOTE r-oldrel-macos-arm64

installed package size

  installed size is 29.4Mb
  sub-directories of 1Mb or more:
    libs  27.8Mb
NOTE r-oldrel-macos-x86_64

installed package size

  installed size is 31.0Mb
  sub-directories of 1Mb or more:
    libs  29.3Mb

Dependency Network

Dependencies Reverse dependencies Rcpp nloptr Matrix Rfast trust parallelly doFuture future (>= 1.32.0) foreach doRNG Seurat SingleCellExperiment nebula

Version History

new 1.5.6 Mar 9, 2026