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Exploratory Subgroup Identification in Clinical Trials with Survival Endpoints
Description
Implements statistical methods for exploratory subgroup identification in clinical trials with survival endpoints. Provides tools for identifying patient subgroups with differential treatment effects using machine learning approaches including Generalized Random Forests (GRF), LASSO regularization, and exhaustive combinatorial search algorithms. Features bootstrap bias correction using infinitesimal jackknife methods to address selection bias in post-hoc analyses. Designed for clinical researchers conducting exploratory subgroup analyses in randomized controlled trials, particularly for multi-regional clinical trials (MRCT) requiring regional consistency evaluation. Supports both accelerated failure time (AFT) and Cox proportional hazards models with comprehensive diagnostic and visualization tools. Methods are described in León et al. (2024) <doi:10.1002/sim.10163>.
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CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | OK |
| r-devel-linux-x86_64-debian-gcc | OK |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-x86_64 | NOTE |
| r-oldrel-windows-x86_64 | NOTE |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (2 non-OK)
installed package size
installed size is 6.1Mb
sub-directories of 1Mb or more:
doc 4.6Mb
installed package size
installed size is 6.1Mb
sub-directories of 1Mb or more:
doc 4.6Mb
Check History
NOTE 4 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 23, 2026
installed package size
installed size is 6.1Mb
sub-directories of 1Mb or more:
doc 4.6Mb