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Finding Allele-Specific Copy Number in Whole-Exome Sequencing Data

v0.2 · Feb 24, 2017 · GPL (>= 2)

Description

This is a method for Allele-specific DNA Copy Number profiling for whole-Exome sequencing data. Given the allele-specific coverage and site biases at the variant loci, this program segments the genome into regions of homogeneous allele-specific copy number. It requires, as input, the read counts for each variant allele in a pair of case and control samples, as well as the site biases. For detection of somatic mutations, the case and control samples can be the tumor and normal sample from the same individual. The implemented method is based on the paper: Chen, H., Jiang, Y., Maxwell, K., Nathanson, K. and Zhang, N. (under review). Allele-specific copy number estimation by whole Exome sequencing.

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r-devel-linux-x86_64-fedora-clang OK
r-devel-linux-x86_64-fedora-gcc OK
r-devel-macos-arm64 OK
r-devel-windows-x86_64 OK
r-oldrel-macos-arm64 OK
r-oldrel-macos-x86_64 OK
r-oldrel-windows-x86_64 OK
r-patched-linux-x86_64 OK
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NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘Hao Chen <hxchen@ucdavis.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Hao",
                      family = "Chen",
                      role = c("aut", "cre"),
                      email = "hxchen@ucdavis.edu"),
               person(given = c("Nancy", "R."),
                      family = "Zhang",
                      role = "aut"))
as necessary.
NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘Hao Chen <hxchen@ucdavis.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Hao",
                      family = "Chen",
                      role = c("aut", "cre"),
                      email = "hxchen@ucdavis.edu"),
               person(given = c("Nancy", "R."),
                      family = "Zhang",
                      role = "aut"))
as necessary.
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NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026
NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘Hao Chen <hxchen@ucdavis.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Hao",
                      family = "Chen",
                      role = c("aut", "cre"),
                      email = "hxchen@ucdavis.edu"),
               person(given = c("Nancy", "R."),
                      family = "Zhang",
                      role = "aut"))
as necessary.
NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘Hao Chen <hxchen@ucdavis.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Hao",
                      family = "Chen",
                      role = c("aut", "cre"),
                      email = "hxchen@ucdavis.edu"),
               person(given = c("Nancy", "R."),
                      family = "Zhang",
                      role = "aut"))
as necessary.

Version History

new 0.2 Mar 10, 2026