crmPack

Description

Implements a wide range of dose escalation designs. The focus is on model-based designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy to setup a new design with custom JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules. Further details are presented in Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

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CRAN Check Status

  installed size is  8.5Mb
  sub-directories of 1Mb or more:
    R      2.0Mb
    doc    4.2Mb
    help   1.3Mb

  installed size is  9.4Mb
  sub-directories of 1Mb or more:
    R      2.0Mb
    doc    4.2Mb
    help   2.2Mb

  installed size is  8.1Mb
  sub-directories of 1Mb or more:
    R      1.6Mb
    doc    4.2Mb
    help   1.3Mb

Check History

  installed size is  8.5Mb
  sub-directories of 1Mb or more:
    R      2.0Mb
    doc    4.2Mb
    help   1.3Mb

  installed size is  9.4Mb
  sub-directories of 1Mb or more:
    R      2.0Mb
    doc    4.2Mb
    help   2.2Mb

  installed size is  8.1Mb
  sub-directories of 1Mb or more:
    R      1.6Mb
    doc    4.2Mb
    help   1.3Mb

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