adestr

Estimation in Optimal Adaptive Two-Stage Designs

v1.0.0 · Jul 12, 2024 · GPL (>= 2)

Description

Methods to evaluate the performance characteristics of various point and interval estimators for optimal adaptive two-stage designs as described in Meis et al. (2024) <doi:10.1002/sim.10020>. Specifically, this package is written to work with trial designs created by the 'adoptr' package (Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09>; Pilz et al. (2021) <doi:10.1002/sim.8953>)). Apart from the a priori evaluation of performance characteristics, this package also allows for the evaluation of the implemented estimators on real datasets, and it implements methods to calculate p-values.

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3 OK

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Flavor	Status	Time
r-devel-linux-x86_64-debian-clang	NOTE	275.8s
r-devel-linux-x86_64-debian-gcc	NOTE	162s
r-devel-linux-x86_64-fedora-clang	NOTE	435.8s
r-devel-linux-x86_64-fedora-gcc	NOTE	447.4s
r-devel-macos-arm64	NOTE	62s
r-devel-windows-x86_64	NOTE	247s
r-oldrel-macos-arm64	OK
r-oldrel-macos-x86_64	OK	134s
r-oldrel-windows-x86_64	OK	356s
r-patched-linux-x86_64	NOTE	259.2s
r-release-linux-x86_64	NOTE	261.6s
r-release-macos-arm64	NOTE
r-release-macos-x86_64	NOTE	181s
r-release-windows-x86_64	NOTE	249s

Check details (14 non-OK)

NOTE r-devel-linux-x86_64-debian-clang

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-devel-linux-x86_64-debian-gcc

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-devel-linux-x86_64-fedora-clang

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-devel-linux-x86_64-fedora-gcc

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-devel-macos-arm64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-devel-windows-x86_64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    'IntervalEstimator-class.Rd' 'PValue-class.Rd'
    'PointEstimator-class.Rd' 'analyze.R' 'estimators.R'
    'evaluate_estimator.R' 'fisher_information.R'
    'integrate_over_sample_space.R' 'mle_distribution.R' 'n2c2_helpers.R'
    'plot.R' 'print.R' 'reference_implementation.R'

OK r-oldrel-macos-arm64

OK r-oldrel-macos-x86_64

OK r-oldrel-windows-x86_64

NOTE r-patched-linux-x86_64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-release-linux-x86_64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-release-macos-arm64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-release-macos-x86_64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘analyze.R’ ‘estimators.R’ ‘evaluate_estimator.R’
    ‘fisher_information.R’ ‘integrate_over_sample_space.R’
    ‘mle_distribution.R’ ‘n2c2_helpers.R’ ‘plot.R’ ‘print.R’
    ‘reference_implementation.R’

NOTE r-release-windows-x86_64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    'IntervalEstimator-class.Rd' 'PValue-class.Rd'
    'PointEstimator-class.Rd' 'analyze.R' 'estimators.R'
    'evaluate_estimator.R' 'fisher_information.R'
    'integrate_over_sample_space.R' 'mle_distribution.R' 'n2c2_helpers.R'
    'plot.R' 'print.R' 'reference_implementation.R'

Changelog

Full NEWS →

v1.0.0

# adestr 1.0.0

• Adding in all the test cases and improvements to the documentation that
were developed collaboratively. Also preparing new CRAN release.

Check History

NOTE 3 OK · 11 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026

NOTE r-devel-linux-x86_64-debian-clang

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-devel-linux-x86_64-debian-gcc

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-devel-linux-x86_64-fedora-clang

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-devel-linux-x86_64-fedora-gcc

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-devel-macos-arm64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-devel-windows-x86_64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    'IntervalEstimator-class.Rd' 'PValue-class.Rd'
    'PointEstimator-class.Rd' 'analyze.R' 'estimators.R'
    'evaluate_estimator.R' 'fisher_information.R'
    'integrate_over_sample_space.R' 'mle_distribution.R' 'n2c2_helpers.R'
    'plot.R' 'print.R' 'reference_implementation.R'

NOTE r-patched-linux-x86_64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-release-linux-x86_64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-release-macos-arm64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘IntervalEstimator-class.Rd’ ‘PValue-class.Rd’
    ‘PointEstimator-class.Rd’ ‘analyze.R’ ‘estimators.R’
    ‘evaluate_estimator.R’ ‘fisher_information.R’
    ‘integrate_over_sample_space.R’ ‘mle_distribution.R’ ‘n2c2_helpers.R’
    ‘plot.R’ ‘print.R’ ‘reference_implementation.R’

NOTE r-release-macos-x86_64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    ‘analyze.R’ ‘estimators.R’ ‘evaluate_estimator.R’
    ‘fisher_information.R’ ‘integrate_over_sample_space.R’
    ‘mle_distribution.R’ ‘n2c2_helpers.R’ ‘plot.R’ ‘print.R’
    ‘reference_implementation.R’

NOTE r-release-windows-x86_64

DESCRIPTION meta-information

  Missing dependency on R >= 4.1.0 because package code uses the pipe
  |> or function shorthand \(...) syntax added in R 4.1.0.
  File(s) using such syntax:
    'IntervalEstimator-class.Rd' 'PValue-class.Rd'
    'PointEstimator-class.Rd' 'analyze.R' 'estimators.R'
    'evaluate_estimator.R' 'fisher_information.R'
    'integrate_over_sample_space.R' 'mle_distribution.R' 'n2c2_helpers.R'
    'plot.R' 'print.R' 'reference_implementation.R'

Dependency Network

Version History

new 1.0.0 Mar 9, 2026

Maintainer

Jan Meis

Dependencies

Depends

R (>= 4.0.0) adoptr

Imports

methods stats grDevices cubature ggplot2 ggpubr scales latex2exp forcats future.apply progressr Rdpack

Suggests

covr knitr rmarkdown testthat (>= 3.0.0) microbenchmark

Compilation

Needs compilation

First Published

Mar 9, 2026

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CRAN Checks

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