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Phase123

Simulating and Conducting Phase 123 Trials

v2.1 · Apr 25, 2019 · GPL-2

Description

Contains three simulation functions for implementing the entire Phase 123 trial and the separate Eff-Tox and Phase 3 portions of the trial, which may be beneficial for use on clusters. The functions AssignEffTox() and RandomizeEffTox() assign doses to patient cohorts during phase 12 and Reoptimize() determines the optimal dose to continue with during Phase 3. The functions ReturnMeansAgent() and ReturnMeanControl() gives the true mean survival for the agent doses and control and ReturnOCS() gives the operating characteristics of the design.

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Maintainer: ‘Andrew G Chapple <achapp@lsuhsc.edu>’

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CRAN incoming feasibility

Maintainer: ‘Andrew G Chapple <achapp@lsuhsc.edu>’

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  Authors@R: person(given = c("Andrew", "G"),
                    family = "Chapple",
                    role = c("aut", "cre"),
                    email = "achapp@lsuhsc.edu")
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NOTE 9 OK · 5 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026
NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘Andrew G Chapple <achapp@lsuhsc.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: person(given = c("Andrew", "G"),
                    family = "Chapple",
                    role = c("aut", "cre"),
                    email = "achapp@lsuhsc.edu")
as necessary.
NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘Andrew G Chapple <achapp@lsuhsc.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: person(given = c("Andrew", "G"),
                    family = "Chapple",
                    role = c("aut", "cre"),
                    email = "achapp@lsuhsc.edu")
as necessary.
NOTE r-oldrel-macos-arm64

LazyData

  'LazyData' is specified without a 'data' directory
NOTE r-oldrel-macos-x86_64

LazyData

  'LazyData' is specified without a 'data' directory
NOTE r-oldrel-windows-x86_64

LazyData

  'LazyData' is specified without a 'data' directory

Dependency Network

Dependencies Reverse dependencies Rcpp survival Phase123

Version History

new 2.1 Mar 9, 2026