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MixTwice

Large-Scale Hypothesis Testing by Variance Mixing

v2.0 · Mar 2, 2022 · GPL-2

Description

Implements large-scale hypothesis testing by variance mixing. It takes two statistics per testing unit -- an estimated effect and its associated squared standard error -- and fits a nonparametric, shape-constrained mixture separately on two latent parameters. It reports local false discovery rates (lfdr) and local false sign rates (lfsr). Manuscript describing algorithm of MixTwice: Zheng et al(2021) <doi: 10.1093/bioinformatics/btab162>.

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CRAN incoming feasibility

Maintainer: ‘Zihao Zheng <zihao.zheng@wisc.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Zihao",
                      family = "Zheng",
                      role = c("aut", "cre"),
                      email = "zihao.zheng@wisc.edu"),
               person(given = "Michael",
                      family = "A.Newton",
                      role = "aut"))
as necessary.
NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘Zihao Zheng <zihao.zheng@wisc.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Zihao",
                      family = "Zheng",
                      role = c("aut", "cre"),
                      email = "zihao.zheng@wisc.edu"),
               person(given = "Michael",
                      family = "A.Newton",
                      role = "aut"))
as necessary.
NOTE r-devel-linux-x86_64-fedora-clang

dependencies in R code

Namespaces in Imports field not imported from:
  ‘ashr’ ‘fdrtool’
  All declared Imports should be used.
NOTE r-devel-linux-x86_64-fedora-gcc

dependencies in R code

Namespaces in Imports field not imported from:
  ‘ashr’ ‘fdrtool’
  All declared Imports should be used.
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Check History

NOTE 10 OK · 4 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026
NOTE r-devel-linux-x86_64-debian-clang

CRAN incoming feasibility

Maintainer: ‘Zihao Zheng <zihao.zheng@wisc.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Zihao",
                      family = "Zheng",
                      role = c("aut", "cre"),
                      email = "zihao.zheng@wisc.edu"),
               person(given = "Michael",
                      family = "A.Newton",
                      role = "aut"))
as necessary.
NOTE r-devel-linux-x86_64-debian-gcc

CRAN incoming feasibility

Maintainer: ‘Zihao Zheng <zihao.zheng@wisc.edu>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = "Zihao",
                      family = "Zheng",
                      role = c("aut", "cre"),
                      email = "zihao.zheng@wisc.edu"),
               person(given = "Michael",
                      family = "A.Newton",
                      role = "aut"))
as necessary.
NOTE r-devel-linux-x86_64-fedora-clang

dependencies in R code

Namespaces in Imports field not imported from:
  ‘ashr’ ‘fdrtool’
  All declared Imports should be used.
NOTE r-devel-linux-x86_64-fedora-gcc

dependencies in R code

Namespaces in Imports field not imported from:
  ‘ashr’ ‘fdrtool’
  All declared Imports should be used.

Dependency Network

Dependencies Reverse dependencies alabama ashr fdrtool Iso MixTwice

Version History

new 2.0 Mar 9, 2026