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LTFHPlus

Implementation of LT-FH++

v2.2.0 · Nov 17, 2025 · GPL-3

Description

Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) <doi:10.1016/j.ajhg.2022.01.009> as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) <https://www.nature.com/articles/s41467-023-41210-z> as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.

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OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026

Dependency Network

Dependencies Reverse dependencies batchmeans dplyr future.apply future purrr Rcpp rlang stringr tibble tmvtnorm tidyselect igraph xgboost tidyr ggplot2 LTFHPlus

Version History

new 2.2.0 Mar 10, 2026