Description
This is a stochastic framework that combines biochemical reaction networks with extended Kalman filter and Rauch-Tung-Striebel smoothing. This framework allows to investigate the dynamics of cell differentiation from high-dimensional clonal tracking data subject to measurement noise, false negative errors, and systematically unobserved cell types. Our tool can provide statistical support to biologists in gene therapy clonal tracking studies for a deeper understanding of clonal reconstitution dynamics. Further details on the methods can be found in L. Del Core et al., (2022) <doi:10.1101/2022.07.08.499353>.
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| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | NOTE |
| r-devel-linux-x86_64-fedora-gcc | NOTE |
| r-devel-macos-arm64 | NOTE |
| r-devel-windows-x86_64 | NOTE |
| r-oldrel-macos-arm64 | NOTE |
| r-oldrel-macos-x86_64 | NOTE |
| r-oldrel-windows-x86_64 | NOTE |
| r-patched-linux-x86_64 | NOTE |
| r-release-linux-x86_64 | NOTE |
| r-release-macos-arm64 | NOTE |
| r-release-macos-x86_64 | NOTE |
| r-release-windows-x86_64 | NOTE |
Check details (14 non-OK)
NOTE
r-devel-linux-x86_64-debian-clang
Rd files
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r-devel-linux-x86_64-debian-gcc
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r-devel-linux-x86_64-fedora-clang
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r-devel-linux-x86_64-fedora-gcc
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r-devel-macos-arm64
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r-devel-windows-x86_64
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r-oldrel-macos-arm64
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checkRd: (-1) get.fit.Rd:78: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:79: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:80: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.sim.trajectories.Rd:66: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.sim.trajectories.Rd:67: Lost braces in \itemize; \value handles \item{}{} directly
NOTE
r-release-linux-x86_64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:57-60: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:61-62: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:63-64: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:70: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:71: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:72: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:73: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:74: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:75: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:76: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:77: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:78: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:79: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:80: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.sim.trajectories.Rd:66: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.sim.trajectories.Rd:67: Lost braces in \itemize; \value handles \item{}{} directly
NOTE
r-release-macos-arm64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:57-60: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:61-62: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:63-64: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:70: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:71: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:72: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:73: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:74: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:75: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:76: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:77: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:78: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:79: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:80: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.sim.trajectories.Rd:66: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.sim.trajectories.Rd:67: Lost braces in \itemize; \value handles \item{}{} directly
NOTE
r-release-macos-x86_64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:57-60: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:61-62: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:63-64: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:70: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:71: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:72: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:73: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:74: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:75: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:76: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:77: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:78: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:79: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:80: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.sim.trajectories.Rd:66: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.sim.trajectories.Rd:67: Lost braces in \itemize; \value handles \item{}{} directly
NOTE
r-release-windows-x86_64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:57-60: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:61-62: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:63-64: Lost braces in \itemize; meant \describe ?
checkRd: (-1) get.fit.Rd:70: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:71: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:72: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:73: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:74: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:75: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:76: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:77: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:78: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:79: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.fit.Rd:80: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.sim.trajectories.Rd:66: Lost braces in \itemize; \value handles \item{}{} directly
checkRd: (-1) get.sim.trajectories.Rd:67: Lost braces in \itemize; \value handles \item{}{} directly
Check History
NOTE 0 OK · 14 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026
NOTE
r-devel-linux-x86_64-debian-clang
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-devel-linux-x86_64-debian-gcc
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-devel-linux-x86_64-fedora-clang
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-devel-linux-x86_64-fedora-gcc
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-devel-macos-arm64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-devel-windows-x86_64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-patched-linux-x86_64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-release-linux-x86_64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-release-macos-arm64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-release-macos-x86_64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-release-windows-x86_64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-oldrel-macos-arm64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-oldrel-macos-x86_64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
NOTE
r-oldrel-windows-x86_64
Rd files
checkRd: (-1) get.fit.Rd:46: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:47: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:48-49: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:50-51: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:52-54: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:55: Lost braces in \itemize; meant \describe ? checkRd: (-1) get.fit.Rd:56: Lost braces in \itemize; meant
Dependency Network
Version History
new
1.0
Mar 9, 2026