HDMT
A Multiple Testing Procedure for High-Dimensional Mediation Hypotheses
Description
A multiple-testing procedure for high-dimensional mediation hypotheses. Mediation analysis is of rising interest in epidemiology and clinical trials. Among existing methods for mediation analyses, the popular joint significance (JS) test yields an overly conservative type I error rate and therefore low power. In the R package 'HDMT' we implement a multiple-testing procedure that accurately controls the family-wise error rate (FWER) and the false discovery rate (FDR) when using JS for testing high-dimensional mediation hypotheses. The core of our procedure is based on estimating the proportions of three component null hypotheses and deriving the corresponding mixture distribution of null p-values. Results of the data examples include better-behaved quantile-quantile plots and improved detection of novel mediation relationships on the role of DNA methylation in genetic regulation of gene expression. With increasing interest in mediation by molecular intermediaries such as gene expression, the proposed method addresses an unmet methodological challenge. Methods used in the package refer to James Y. Dai, Janet L. Stanford & Michael LeBlanc (2020) <doi:10.1080/01621459.2020.1765785>.
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CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | OK |
| r-devel-linux-x86_64-debian-gcc | OK |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check History
OK 13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Jun 5, 2026
ERROR 12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Jun 1, 2026
whether package can be installed
Installation failed. See 'd:/Rcompile/CRANpkg/local/4.7/HDMT.Rcheck/00install.out' for details.
OK 13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE May 27, 2026
ERROR 12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE May 24, 2026
whether package can be installed
Installation failed. See 'd:/Rcompile/CRANpkg/local/4.7/HDMT.Rcheck/00install.out' for details.
OK 13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE May 14, 2026
ERROR 12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE May 11, 2026
whether package can be installed
Installation failed. See 'd:/Rcompile/CRANpkg/local/4.7/HDMT.Rcheck/00install.out' for details.
OK 13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE May 6, 2026
ERROR 12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE May 4, 2026
whether package can be installed
Installation failed. See 'd:/Rcompile/CRANpkg/local/4.7/HDMT.Rcheck/00install.out' for details.
OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Apr 24, 2026
ERROR 13 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Apr 22, 2026
whether package can be installed
Installation failed. See 'd:/Rcompile/CRANpkg/local/4.6/HDMT.Rcheck/00install.out' for details.
OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Apr 16, 2026
ERROR 13 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Apr 15, 2026
whether package can be installed
Installation failed. See 'd:/Rcompile/CRANpkg/local/4.6/HDMT.Rcheck/00install.out' for details.
OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Apr 9, 2026
ERROR 13 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Apr 7, 2026
whether package can be installed
Installation failed. See 'd:/Rcompile/CRANpkg/local/4.6/HDMT.Rcheck/00install.out' for details.
OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Apr 2, 2026
ERROR 13 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Mar 20, 2026
whether package can be installed
Installation failed. See 'd:/Rcompile/CRANpkg/local/4.6/HDMT.Rcheck/00install.out' for details.