GEVACO
Joint Test of Gene and GxE Interactions via Varying Coefficients
Description
A novel statistical model to detect the joint genetic and dynamic gene-environment (GxE) interaction with continuous traits in genetic association studies. It uses varying-coefficient models to account for different GxE trajectories, regardless whether the relationship is linear or not. The package includes one function, GxEtest(), to test a single genetic variant (e.g., a single nucleotide polymorphism or SNP), and another function, GxEscreen(), to test for a set of genetic variants. The method involves a likelihood ratio test described in Crainiceanu, C. M., and Ruppert, D. (2004) <doi:10.1111/j.1467-9868.2004.00438.x>.
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CRAN Check Status
Show all 14 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (14 non-OK)
CRAN incoming feasibility
Maintainer: ‘Sydney Manning <sydney.manning@unthsc.edu>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Zhengyang",
family = "Zhou",
role = "aut"),
person(given = "Sydney",
family = "Manning",
role = "cre",
email = "sydney.manning@unthsc.edu"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Sydney Manning <sydney.manning@unthsc.edu>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Zhengyang",
family = "Zhou",
role = "aut"),
person(given = "Sydney",
family = "Manning",
role = "cre",
email = "sydney.manning@unthsc.edu"))
as necessary.
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Check History
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026
CRAN incoming feasibility
Maintainer: ‘Sydney Manning <sydney.manning@unthsc.edu>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Zhengyang",
family = "Zhou",
role = "aut"),
person(given = "Sydney",
family = "Manning",
role = "cre",
email = "sydney.manning@unthsc.edu"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Sydney Manning <sydney.manning@unthsc.edu>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Zhengyang",
family = "Zhou",
role = "aut"),
person(given = "Sydney",
family = "Manning",
role = "cre",
email = "sydney.manning@unthsc.edu"))
as necessary.