Description
Package implements the EDNE-test for equivalence according to Hoffelder et al. (2015) <DOI:10.1080/10543406.2014.920344>. "EDNE" abbreviates "Euclidean Distance between the Non-standardized Expected values". The EDNE-test for equivalence is a multivariate two-sample equivalence test. Distance measure of the test is the Euclidean distance. The test is an asymptotically valid test for the family of distributions fulfilling the assumptions of the multivariate central limit theorem (see Hoffelder et al.,2015). The function EDNE.EQ() implements the EDNE-test for equivalence according to Hoffelder et al. (2015). The function EDNE.EQ.dissolution.profiles() implements a variant of the EDNE-test for equivalence analyses of dissolution profiles (see Suarez-Sharp et al.,2020 <DOI:10.1208/s12248-020-00458-9>). EDNE.EQ.dissolution.profiles() checks whether the quadratic mean of the differences of the expected values of both dissolution profile populations is statistically significantly smaller than 10 [\% of label claim]. The current regulatory standard approach for equivalence analyses of dissolution profiles is the similarity factor f2. The statistical hypotheses underlying EDNE.EQ.dissolution.profiles() coincide with the hypotheses for f2 (see Hoffelder et al.,2015, Suarez-Sharp et al., 2020).
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Check details (2 non-OK)
CRAN incoming feasibility
Maintainer: ‘Thomas Hoffelder <thomas.hoffelder@boehringer-ingelheim.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = "Thomas",
family = "Hoffelder",
role = c("aut", "cre"),
email = "thomas.hoffelder@boehringer-ingelheim.com")
as necessary.
Found the following URLs which should use \doi (with the DOI name only):
File ‘EDNE.EQ-package.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
http://dx.doi.org/10.1208/s12248-020-00458-9
File ‘EDNE.EQ.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
File ‘EDNE.EQ.dissolution.profiles.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
http://dx.doi.org/10.1208/s12248-020-00458-9
File ‘ex_data_JoBS.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
CRAN incoming feasibility
Maintainer: ‘Thomas Hoffelder <thomas.hoffelder@boehringer-ingelheim.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = "Thomas",
family = "Hoffelder",
role = c("aut", "cre"),
email = "thomas.hoffelder@boehringer-ingelheim.com")
as necessary.
Found the following URLs which should use \doi (with the DOI name only):
File ‘EDNE.EQ-package.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
http://dx.doi.org/10.1208/s12248-020-00458-9
File ‘EDNE.EQ.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
File ‘EDNE.EQ.dissolution.profiles.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
http://dx.doi.org/10.1208/s12248-020-00458-9
File ‘ex_data_JoBS.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
Check History
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
CRAN incoming feasibility
Maintainer: ‘Thomas Hoffelder <thomas.hoffelder@boehringer-ingelheim.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = "Thomas",
family = "Hoffelder",
role = c("aut
...[truncated]...
rg/10.1080/10543406.2014.920344
File ‘EDNE.EQ.dissolution.profiles.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
http://dx.doi.org/10.1208/s12248-020-00458-9
File ‘ex_data_JoBS.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
CRAN incoming feasibility
Maintainer: ‘Thomas Hoffelder <thomas.hoffelder@boehringer-ingelheim.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = "Thomas",
family = "Hoffelder",
role = c("aut
...[truncated]...
rg/10.1080/10543406.2014.920344
File ‘EDNE.EQ.dissolution.profiles.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344
http://dx.doi.org/10.1208/s12248-020-00458-9
File ‘ex_data_JoBS.Rd’:
http://dx.doi.org/10.1080/10543406.2014.920344