CKLRT
Composite Kernel Machine Regression Based on Likelihood Ratio Test
Description
Composite Kernel Machine Regression based on Likelihood Ratio Test (CKLRT): in this package, we develop a kernel machine regression framework to model the overall genetic effect of a SNP-set, considering the possible GE interaction. Specifically, we use a composite kernel to specify the overall genetic effect via a nonparametric function and we model additional covariates parametrically within the regression framework. The composite kernel is constructed as a weighted average of two kernels, one corresponding to the genetic main effect and one corresponding to the GE interaction effect. We propose a likelihood ratio test (LRT) and a restricted likelihood ratio test (RLRT) for statistical significance. We derive a Monte Carlo approach for the finite sample distributions of LRT and RLRT statistics. (N. Zhao, H. Zhang, J. Clark, A. Maity, M. Wu. Composite Kernel Machine Regression based on Likelihood Ratio Test with Application for Combined Genetic and Gene-environment Interaction Effect (Submitted).)
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| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | NOTE |
| r-oldrel-macos-x86_64 | NOTE |
| r-oldrel-windows-x86_64 | NOTE |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (16 non-OK)
CRAN incoming feasibility
Maintainer: ‘Haoyu Zhang <andrew.haoyu@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Ni",
family = "Zhao",
role = "aut"),
person(given = "Haoyu",
family = "Zhang",
role = c("aut", "cre"),
email = "andrew.haoyu@gmail.com"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Haoyu Zhang <andrew.haoyu@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Ni",
family = "Zhao",
role = "aut"),
person(given = "Haoyu",
family = "Zhang",
role = c("aut", "cre"),
email = "andrew.haoyu@gmail.com"))
as necessary.
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LazyData
'LazyData' is specified without a 'data' directory
installed package size
installed size is 21.2Mb
sub-directories of 1Mb or more:
libs 20.9Mb
LazyData
'LazyData' is specified without a 'data' directory
installed package size
installed size is 21.4Mb
sub-directories of 1Mb or more:
libs 21.1Mb
LazyData
'LazyData' is specified without a 'data' directory
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Check History
NOTE 9 OK · 5 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 9, 2026
CRAN incoming feasibility
Maintainer: ‘Haoyu Zhang <andrew.haoyu@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Ni",
family = "Zhao",
role = "aut"),
person(given = "Haoyu",
family = "Zhang",
role = c("aut", "cre"),
email = "andrew.haoyu@gmail.com"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Haoyu Zhang <andrew.haoyu@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Ni",
family = "Zhao",
role = "aut"),
person(given = "Haoyu",
family = "Zhang",
role = c("aut", "cre"),
email = "andrew.haoyu@gmail.com"))
as necessary.
installed package size
installed size is 21.2Mb
sub-directories of 1Mb or more:
libs 20.9Mb
installed package size
installed size is 21.4Mb
sub-directories of 1Mb or more:
libs 21.1Mb
LazyData
'LazyData' is specified without a 'data' directory