ActiveDriverWGS

A Driver Discovery Tool for Cancer Whole Genomes

v1.2.1 · Mar 13, 2026 · GPL-3

Description

A method for finding enrichments of somatic single nucleotide variants (SNVs) and small insertions-deletions (Indels) in functional elements in the human genome. 'ActiveDriverWGS' detects coding and noncoding cancer driver elements using whole genome sequencing data. The method is part of the publication H. Zhu et al. (2020) <doi:10.1016/j.molcel.2019.12.027> "Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks" in Molecular Cell.

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2 NOTE

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Flavor	Status	Time
r-devel-linux-x86_64-debian-clang	OK	158.2s
r-devel-linux-x86_64-debian-gcc	OK	114.7s
r-devel-linux-x86_64-fedora-clang	OK	306.4s
r-devel-linux-x86_64-fedora-gcc	OK	319s
r-devel-macos-arm64	OK	55s
r-devel-windows-x86_64	OK	173s
r-oldrel-macos-arm64	NOTE	83s
r-oldrel-macos-x86_64	NOTE	129s
r-oldrel-windows-x86_64	OK	223s
r-patched-linux-x86_64	OK	148.5s
r-release-linux-x86_64	OK	147.7s
r-release-macos-arm64	OK	58s
r-release-macos-x86_64	OK	128s
r-release-windows-x86_64	OK	168s

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NOTE r-oldrel-macos-arm64

package dependencies

Packages suggested but not available for checking:
  'BSgenome.Hsapiens.UCSC.hg19', 'BSgenome.Hsapiens.UCSC.hg38',
  'BSgenome.Mmusculus.UCSC.mm9', 'BSgenome.Mmusculus.UCSC.mm10'

NOTE r-oldrel-macos-x86_64

package dependencies

Packages suggested but not available for checking:
  'BSgenome.Hsapiens.UCSC.hg19', 'BSgenome.Hsapiens.UCSC.hg38',
  'BSgenome.Mmusculus.UCSC.mm9', 'BSgenome.Mmusculus.UCSC.mm10'

Changelog

Full NEWS →

v1.2.1

# ActiveDriverWGS 1.2.1

• Bug fixed: elements and sites with coordinates below 2 or beyond the chromosome end now return an informative error, preventing downstream failures in trinucleotide context calculations.
• Bug fixed: all GenomicRanges operations (findOverlaps, setdiff, intersect, union) now use ignore.strand = TRUE, ensuring mutations, elements, and sites are always matched by genomic position regardless of strand.

Check History

NOTE 4 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 13, 2026

NOTE r-oldrel-macos-arm64

package dependencies

Packages suggested but not available for checking:
  'BSgenome.Hsapiens.UCSC.hg19', 'BSgenome.Hsapiens.UCSC.hg38',
  'BSgenome.Mmusculus.UCSC.mm9', 'BSgenome.Mmusculus.UCSC.mm10'

Dependency Network

Version History

new 1.2.1 Mar 13, 2026